| 张琪,张蕾,颜贤忠,王丽华,刘卫红,陈合兵.三仁汤对大鼠高脂血症模型血脂及代谢产物谱的影响[J].中国中西医结合杂志,2011,31(1):52-57 |
| 三仁汤对大鼠高脂血症模型血脂及代谢产物谱的影响 |
| Effects of Sanren Decoction on Plasma Lipids and the Metabolic Profiles of Hyperlipidemia Rat Model |
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| DOI： |
| 中文关键词: 高脂血症 三仁汤 三焦气化 代谢组学 |
| 英文关键词:hyperlipidemia Sanren Decoction Sanjiao gasification metabonomics |
| 基金项目:国家自然科学基金资助项目(No.30873314);北京市自然科学基金资助项目(No.7072013) |
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| 中文摘要: |
| 目的探讨三仁汤及拆方对大鼠高脂血症模型血脂及代谢产物谱的影响。方法采用高脂饲料喂饲法复制大鼠高脂血症模型。采用随机数字表法随机分为正常对照组(正常组)、模型组、三仁汤组、上焦方组、中焦方组、下焦方组及阿托伐他汀钙组(对照组),每组10只。选择调畅三焦气机的经典代表方剂三仁汤,并根据其组方原理、配伍及功效,将该方拆为上焦方、中焦方和下焦方,采用核磁共振的代谢组学技术和生化分析技术,观察在三仁汤全方及不同拆方干预下,高脂血症模型大鼠血脂及代谢产物谱的变化情况。结果与正常组比较,模型组第3周血胆固醇水平明显升高(P<0.05),与模型组比较,三仁汤及不同拆方均有不同程度地降低胆固醇水平作用(P<0.05,P<0.01),且三仁汤的降脂作用优于上焦方组(P<0.05)。主成分分析法能将模型组、正常组、三仁汤组与上焦方、中焦方和下焦方各拆方组明显区分开,三仁汤组优于各拆方组。表明通过合理组方,整体调节三焦气化功能对改善血脂水平的作用优于单一对上焦、中焦和下焦气化功能的调节。结论三焦气化理论对高脂血症的治疗具有一定的指导作用。 |
| 英文摘要: |
| Objective To investigate the effects of Sanren Decoction and its separated recipe on the plasma lipids and metabolic profiles of hyperlipidemia rat model. Methods The hyperlipidemia rat model was established by feeding with high fat diet. Male Wistar rats were randomly divided into the normal control group (normal group),model group,the Shangjiao group,the Zhongjiao group,the Xiajiao group,Sanren group and Atorvastatin calcium group (control group),10 in each. Sanren Decoction,a representative recipe based on the Sanjiao theory,and the various combinations of its components based on its compatibility principle were selected. The changes in plasma lipids and metabolic profiles of the model rats were then observed using biochemical methods and NMR-based metabonomic techniques. Results Significant hypercholesterolemia was observed in model rats after three weeks by feeding with high fat diet (P<0.05). Compared with the model group,Sanren Decoction and its separated components reduced plasma cholesterol to various degrees (P<0.05,P<0.01). Besides,Sanren Decoction had better effect than the Shangjiao group (P<0.05). The metabolic profiles of the model rats were different from those of the control groups,the Sanren Decoction group and the three separated components groups. The effect of Sanren Decoction on the model group was better than each separated recipe group. The results demonstrated that the effect on improving the blood lipid levels by overall regulation of Sanjiao was better than those by the regulation of Shangjiao,Zhongjiao or Xiajiao respectively. Conclusions The Sanjiao theory is useful in guiding the treatment of hyperlipidemia. |
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