原发性痛经患者瘀血舌象与血小板活化因子及血小板活化因子乙酰水解酶关系

Correlation between Blood-stasis Tongue Figure and Platelet Activating Factor(PAF) and Acetyl Hydrolase of PAF(PAF-AH) in Patients with Primary Dysmenorrhea

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中文关键词: 原发性痛经瘀血舌象血小板活化因子血小板活化因子乙酰水解酶

英文关键词:primary dysmenorrhea blood-stasis tongue figure platelet activating factor acetyl hydrolase of platelet activating factor

基金项目:国家重点基础研究发展计划(973计划No.2005CB523502);广东省中医药管理局科研课题(No.2008129);广州中医药大学中医药科研创新基金项目(No.2007C013)

作者	单位
杨爱萍	广州中医药大学基础医学院
陈群	广州中医药大学基础医学院

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中文摘要:

目的探讨原发性痛经患者瘀血舌象形成的病理机制。方法随机选择原发性痛经患者41例和健康人20名,采用ELISA法检测血小板活化因子(PAF)和血小板活化因子乙酰水解酶(PAF-AH)水平。结果原发性痛经瘀血舌组(22例)PAF值水平(ng/L)(252.214±37.568)高于非瘀血舌组(212.348±22.794,19例)及健康对照组(182.126±18.306),而PAF-AH值相反[依次分别为(μg/L)3.090±1.483,5.382±1.873,5.607±2.073,P<0.05];非瘀血舌组仅PAF高于健康对照组(P<0.05)。瘀血舌3个中医证型间PAF和PAF-AH比较,差异无统计学意义(P>0.05)。结论原发性痛经瘀血舌象患者外周血中PAF活性明显增高,PAF-AH活性明显降低,PAF-AH与PAF的失衡与原发性痛经瘀血舌象患者发病机制有关。

英文摘要:

Objective To explore the pathologic mechanism of blood-stasis tongue figure(BSTF) formation in patients with primary dysmenorrhea.Methods Blood levels of platelet activating factor(PAF) and acetyl hydrolase of PAF(PAF-AH) in 41 patients with primary dysmenorrhea and 20 healthy subjects were detected by enzyme linked immunosorbent assay(ELISA).Results The level of PAF in the 22 patients with BSTF was 252.214±37.568 ng/L,which was higher than that in patients without BSTF(19 patients,212.348±22.794 ng/L) and healthy subjects(182.126±18.306 ng/L) respectively,while level of PAF-AH showed an opposite sequence in them,i.e.3.090±1.483,5.382±1.873,and 5.607±2.073 ng/L,respectively(P<0.05).Patients without BSTF showed only a higher level of PAF when compared with that in healthy subjects(P<0.05).No significant difference in PAF or PAF-AH levels was shown among patients with BDTF of different Chinese medical syndrome types(P>0.05).Conclusion PAF level obviously increased and PAF-AH level obviously decreased in primary dysmenorrhea patients of BSTF,suggesting that the imbalance of PAF and PAF-AH was correlated with the pathologic mechanism of the BSTF formation in primary dysmenorrhea patients.

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