电针阳明经穴对急性脑梗死患者PAC-1表达及下肢功能恢复的影响

Effect of Electro-needling at Acupoints of the Yangming Meridian on the Expression of PAC-1 and Lower Limb Functions in Acute Cerebral Infarction Patients

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中文关键词: 电针阳明经穴急性脑梗死血小板膜糖蛋白纤维蛋白原受体下肢功能

英文关键词:electro-needling acupoints of the yangming meridian acute cerebral infarction platelet associated complement-1 lower limb function

基金项目:广东省医学科学技术研究基金项目(No.WSTJJ20051101430103590927157)

作者	单位
张炘	南方医科大学珠江医院神经外科广东神经外科研究所
谭峰	广州中医药大学附属佛山中医院
罗斌	南方医科大学珠江医院神经外科广东神经外科研究所
龙霄翱	南方医科大学珠江医院神经外科广东神经外科研究所
黄彪	广州中医药大学附属佛山中医院
方美凤	广州中医药大学附属佛山中医院
段传志	南方医科大学珠江医院神经外科广东神经外科研究所

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中文摘要:

目的观察电针阳明经穴对急性脑梗死(acute cerebral infarction,ACI)患者血小板膜糖蛋白纤维蛋白原受体(PAC-1)表达及瘫痪下肢功能恢复的影响。方法将58例ACI患者随机分为治疗组和对照组。治疗组在常规治疗的基础上给予电针阳明经穴;对照组只给予常规治疗。采用流式细胞仪技术检测两组治疗前后PAC-1含量的变化,并采用简化的下肢运动功能评分(Fugl-Meyer)法评估电针对ACI患者瘫痪下肢功能恢复的影响。同时选取20名健康人进行参考值测定。结果在急性期,ACI患者PAC-1水平较健康人组显著升高(P<0.05)。治疗组治疗后PAC-1水平较治疗前明显降低(P<0.01),对照组治疗前后自身比较差异无统计学意义。治疗2周后,治疗组和对照组Fugl-Meyer评分与治疗前比较,差异有统计学意义(P<0.05),且治疗组Fugl-Meyer评分较对照组治疗后增高,差异有统计学意义(P<0.01)。结论 ACI早期存在血小板活化。电针阳明经穴对PAC-1水平有明显的抑制作用,能改善ACI患者瘫痪下肢功能恢复的程度,推测电针阳明经穴在ACI早期主要通过调控PAC-1水平,从而延缓ACI患者病情进展,促进患者神经功能修复。

英文摘要:

Objective To observe the effect of electro-needling at acupoints of the yangming meridian on the expression of platelet associated complement-1(PAC-1) and lower limb functions in acute cerebral infarction(ACI) patients.Methods 58 ACI patients were randomly assigned to the treatment group and the control group.Conventional therapies were given to all patients.Additionally,the electro-needling at acupoints of the yangming meridian was given to patients in the treatment group.Changes of PAC-1 were detected using flow cytometry.Effect of lower limbs functions of ACI patients before and after electro-needling was assessed using Fugl-Meyer Index.Meanwhile,20 healthy subjects were selected for reference value.Results In the acute stage,the PAC-1 level in ACI patients were significantly higher than that in healthy subjects(P<0.05).The PAC-1 level in the electro-needling group was obviously lowered after treatment(P<0.01).There was no significant difference in the control group between before and after treatment.Significant difference was found in Fugl-Meyer index in the same group between before and after two-week treatment(P<0.05).It was higher in the electro-needling group than in the control group,showing significant difference(P<0.01).Conclusions Platelet activation exists in the acute stage of ACI.Electro-needling at acupoints of the yangming meridian showed obvious inhibition on PAC-1 levels,could improve lower limbs functions of ACI patients.It was inferred that electro-needling at acupoints of the yangming meridian promoted the recovery of paralyzed lower limbs at the early stage mainly by regulating PAC-1 levels,thus postponing the progress of ACI.

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