| 张纨,张金丽,刘雪婷,李佃贵,郭敏,杜艳茹.化浊解毒方对慢性萎缩性胃炎胃癌前病变患者胃液成分及肿瘤标记物的影响[J].中国中西医结合杂志,2011,31(4):496-499 |
| 化浊解毒方对慢性萎缩性胃炎胃癌前病变患者胃液成分及肿瘤标记物的影响 |
| Effect of Huazhuo Jiedu Recipe on Gastric Juice Compositions and Tumor Markers in Patients with Chronic Atrophic Gastritic Precancerosis |
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| DOI： |
| 中文关键词: 化浊解毒 胃癌前病变 胃液 浊毒 肿瘤标记物 |
| 英文关键词:Huazhuo Jiedu Recipe gastric precancerosis the gastric juice turbidity toxin tumor marker |
| 基金项目:河北省科学技术计划项目(No.08206127D) |
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| 中文摘要: |
| 目的观察化浊解毒方对慢性萎缩性胃炎癌前病变的临床疗效及对胃液中乳酸、总酸、亚硝酸盐及游离酸和胃液及血中肿瘤标记物的影响。方法 229例慢性萎缩性胃炎癌前病变患者随机分为两组,治疗组119例给予化浊解毒方口服,对照组110例给予胃复春片口服,3个月为1个疗程,共治疗2个疗程。观察两组临床疗效及胃酸的含量,运用电化学发光免疫分析法检测胃液和血液中肿瘤标记物的含量。结果治疗组临床病理有效率为83.2%(99/119),对照组为60.9%(67/110),两组病理总有效率比较,差异有统计学意义(P<0.05);两组均能显著提高胃液中总酸和游离酸的含量并降低乳酸及亚硝酸盐的含量,且能显著降低胃液及血清中癌胚抗原(carcinoembryonic antigen,CEA)、糖类抗原19-9(carbohydrate antigen19-9,CA19-9)、糖类抗原72-4(carbohydrate antigen72-4,CA72-4)、糖类抗原125(carbohydrate antigen125,CA125)的含量,与对照组比较,治疗组作用更明显(P<0.05)。结论化浊解毒方能刺激胃黏膜的分泌功能,提高胃液总酸度和游离酸的含量;通过降低胃液中乳酸及亚硝酸盐的含量和胃液及血清中CEA、CA19-9、CA72-4、CA125的含量,阻止胃癌前病变的进一步发展。 |
| 英文摘要: |
| Objective To observe clinical efficacy of Huazhuo Jiedu Recipe(HJR) on chronic atrophic gastritic precancerosis(CAGP),and its effect on contents of lactic acid,total acid,free acid,and nitrite in the gastric juice,as well as tumor markers in gastric juice and blood.Methods Two hundred and twenty-nine patients with CAGP were randomly assigned to two groups,the 119 patients in the treated group orally took HJR and the 110 patients in the control group orally took Weifuchun Tablet.The therapeutic course for all was three months,two courses in total.The therapeutic efficacy,changes of gastric acid contents before and after treatment were observed,and the tumor markers in the gastric juice and blood were detected using electrochemical luminescence immunoassay.Results The pathological effective rate was 83.2%(99/119) in the treated group and 60.9%(67/110) in the control group,showing significant difference between the two groups(P<0.05).The total acids and free acids in the gastric juice were significantly improved,contents of lactic acid and nitrite were significantly lowered in the two groups.Both contents of carcinoembryonic antigen(CEA),carbohydrate antigen19-9(CA19-9),carbohydrate antigen72-4(CA72-4),and carbohydrate antigen125(CA125) in the gastric juice and serum were significantly lowered after treatment in the treated group(P<0.05).Compared with the normal control group,the therapeutic effect was more obvious in the treated group(P<0.05).ConclusionsHJR could stimulate the gastric membranous secretion,enhance contents of total acids and free acids.It could prevent the further progress of CAGP by decreasing contents of lactic acid and nitrite in the gastric juice,and lowering contents of CEA,CA19-9,CA72-4,and CA125 in the gastric juice and serum. |
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