子宫肌瘤发病的易患因素及化瘤方的疗效

作者	单位
张婷婷	上海中医药大学附属岳阳中西医结合医院
谭蕾	上海中医药大学附属岳阳中西医结合医院
孟炜	香港浸会大学中医药学院

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中文摘要:

目的观察化瘤方治疗气虚血瘀型子宫肌瘤临床疗效,探讨子宫肌瘤发病易患因素与肌瘤体积及疗效的相关性。方法通过问卷调查获得110例气虚血瘀型肌瘤患者的发病易患因素情况(2005年9月—2007年9月上海市岳阳中西医结合医院妇科门诊患者),随机分为两组,治疗组80例用化瘤方治疗,对照组30例用桂枝茯苓胶囊治疗。观察临床疗效和治疗前后子宫及肌瘤的体积变化,中医证候改善情况,疗效与易患因素的相关性。结果化瘤方组临床总有效率为85.0%(68/80),对照组总有效率为66.7%(20/30),两组比较差异有统计学意义(P<0.05);具有易患因素的患者,治疗组疗效优于对照组,差异有统计学意义(P<0.05)。临床观察肌瘤体积大小与分娩年龄、病程、情绪压力呈正相关。临床疗效与病程、情绪压力、乳腺增生呈负相关。结论化瘤方能有效缩小子宫肌瘤,明显改善临床症状及伴随疾病,防治易患因素可提高临床疗效。

英文摘要:

Objective To observe the clinical efficacy of Hualiu Recipe (HLR) in treating hysteromyoma,and to explore the correlation between the predisposing factors and the tumor volume as well as the therapeutic efficacy. Methods One hundred and ten outpatients with hysteromyoma of qi deficiency blood stasis syndrome were enrolled,who were outpatients of Department of Gynecology,Shanghai Yueyang Hospital of Integrative Medicine from September 2005 to September 2007. Their predisposing factors were collected by questionnaire. They were randomly assigned to two groups. The eighty patients in the treatment group were treated with HLR,while the thirty patients in the control group were treated with Guizhi Fuling Capsule. The clinical efficacy and changes of uterus and tumor volumes before and after treatment,improvement of Chinese syndrome,and the correlation between the therapeutic efficacy and predisposing factors were observed. Results The total effective rate in the treatment group was 85.0% (68/80),while that in the control group was 66.7% (20/30),showing statistical significance (P<0.05). The therapeutic efficacy of patients with predisposing factors was better in the treatment group than in the control group,showing significant difference (P<0.05). The tumor volume was observed to be positively correlated with the delivery age,the disease course,and the emotional stress. The clinical efficacy was negatively correlated with the disease course,the emotional stress,and the hyperplasia of mammary glands. Conclusion HLR could effectively reduce the tumor volume of hysteromyoma,and obviously improve clinical symptoms and accompanied disease. The therapeutic efficacy could be improved by prevention and treatment of predisposing factors.

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