祛敏通鼻喷膜剂治疗常年性变应性鼻炎临床观察

作者	单位
黄健	广东省中医院珠海医院耳鼻咽喉科
符绩雄	广东省中医院珠海医院耳鼻咽喉科
陈欣欣	广东省中医院珠海医院耳鼻咽喉科

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中文摘要:

目的探讨祛敏通鼻喷膜剂局部应用治疗常年性变应性鼻炎的药物作用机制及疗效观察。方法将常年性变应性鼻炎患者103例,随机分为2组,治疗组57例采用祛敏通鼻喷膜剂治疗,对照组46例采用二丙酸倍氯米松喷雾剂(伯克纳)治疗。7天为1个疗程,使用2个疗程。观察患者的临床疗效及治疗前后症状体征积分与血清白介素4(IL-4)、白介素8(IL-8)、IgE水平、总鼻气道阻力(nasal airway resist-ance,NAR)的变化。结果治疗组与对照组显效率(分别为61.40%、63.04%)、总有效率(分别为87.72%、89.13%)比较差异无统计学意义(P>0.05)。治疗后两组症状体征积分均有显著改善,与治疗前比较,差异均有统计学意义(P<0.01);两组治疗后比较,差异无统计学意义(P>0.05)。血清IL-4、IL-8、IgE水平、总NAR,治疗前两用药组与正常组比较均显著增高;治疗后两用药组均显著下降,差异有统计学意义(P<0.01);治疗组与对照组间比较,差异无统计学意义(P>0.05)。结论祛敏通鼻喷膜剂能有效的治疗变应性鼻炎,可明显降低变应性鼻炎患者血清中IL-8、IL-4、IgE水平及总NAR。

英文摘要:

Objective To study the mechanism of action and the the rapeutic efficacy of treating patients with perennial allergic rhinitis by Qumin Tongbi Nasal Spraying Agent (QTNSA). Methods One hundred and three patients with perennial allergic rhinitis were randomly assigned to two groups. Of them,57 patients in the treatment group were treated with QTNSA and 46 patients in the control group were treated with Veconase. Seven days were taken as one therapeutic course,two courses in total. The therapeutic efficacy and the serum levels of interleukin-4 (IL-4),IL-8,immunoglobulin E (IgE) and nasal airway resistance (NAR),symptoms and signs integrals before and after treatment were observed in the two groups. Results There was no statistical significance between the treatment group and the control group in the markedly effective rate (61.40% vs 63.04%) and the total effective rate (87.72% vs 89.13%). After treatment symptoms and signs integrals of the two groups were significantly improved when compared with before treatment (P<0.01). There was no significant difference between the two groups after treatment (P>0.05). The serum levels of IL-4,IL-8,IgE,and NAR were significantly higher in the two groups than those of the normal group. They significantly decreased after treatment in the two groups,showing statistical difference (P<0.01). There was no statistical difference between the treatment group and the control group (P>0.05). Conclusions QTNSA could effectively treat perennial allergic rhinitis. It could obviously lower serum levels of IL-4,IL-8,IgE,and NAR in patients with perennial allergic rhinitis.

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