补肾活血方对慢性肾炎肾虚血瘀证患者蛋白尿、尿IL-6、TGF-β<sub>1</sub>及MCP-1的影响

Effects of Bushen Huoxue Recipe on Urinary Levels of Albumin,IL-6,TGF-β₁ and MCP-1 in Chronic Nephritis Patients of Shen-deficiency Blood-stasis Syndrome

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中文关键词: 补肾活血方慢性肾炎蛋白尿白介素-6 转化生长因子-β1 单核细胞趋化蛋白-1

英文关键词:Bushen Huoxue Recipe chronic nephritis albuminuria interleukin-6 transforming growth factor-β1 monocyte chemotactic protein-1

基金项目:上海市科委重点资助项目(No.01DJ19013)

作者	单位
张红英	上海复旦大学附属华山医院中西医结合科
何立群	上海中医药大学附属曙光医院肾病科
段晓虹	上海复旦大学附属华山医院中西医结合科
董竞成	上海复旦大学附属华山医院中西医结合科

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中文摘要:

目的观察补肾活血方对慢性肾炎肾虚血瘀证患者蛋白尿及尿白介素-6(interleukin-6,IL-6)、转化生长因子-β1(transform ing growth factoβr-1,TGFβ-1)、单核细胞趋化蛋白-1(monocyte chemotactic protein-1,MCP-1)的影响。方法将45例患者按区组随机化方法分为对照组和治疗组。对照组15例,治疗组30例,两组均采用蒙诺10 mg,每天1次口服,治疗组加用补肾活血方,每天2次煎服;两组疗程均为8周,正常组6名,选自曙光医院健康体检者,观察尿24 h蛋白定量、尿TGFβ-1、IL-6、MCP-1含量的变化。结果与治疗前比较,治疗组尿24h蛋白定量明显下降,差异有统计学意义(P<0.01),对照组尿24 h蛋白定量下降,差异有统计学意义(P<0.05),治疗后治疗组与对照组比较,差异有统计学意义(P<0.01);治疗组、对照组与治疗前比较,IL-6、TGFβ-1、MCP-1水平下调,差异有统计学意义(P<0.01),且治疗后治疗组与对照组比较,IL-6、TGFβ-1差异有统计学意义(P<0.05)。结论补肾活血方具有减轻蛋白尿的作用,其机制可能与下调IL-6、TGFβ-1、MCP-1水平有关。

英文摘要:

Objective To observe the effect of Bushen Huoxue Recipe(BSHXR,a Chinese medicine recipe for Shen reinforcing and blood circulation activating) on the levels of urinary albumin,interlukin-6(IL-6),transforming growth factor-β1(TGF-β1),and monocyte chemotactic protein-1(MCP-1) in chronic nephritis patients of Shen-deficiency blood-stasis syndrome.Methods Forty-five patients were blocking assigned randomly to two groups,fifteen patients in the control group and thirty in the treatment group.All orally took Monopril 10 mg,once daily.But BSHXR was given additionally to patients in the treatment group after decocting,one dose per day(taken in two times).The treatment course for both groups was eight weeks.Besides,a normal control group consisting of six healthy subjects from health examination of Shuguang Hospital was set up.The 24-h urinary albumin and contents of TGF-β1,IL-6 and MCP-1 in urine of all subjects were observed.Results Compared with before treatment the 24-h urinary albumin was obviously reduced in the treatment group,showing significant difference(P<0.01).The urinary 24-h albumin decreased in the control group,with statistical significance(P<0.05).Statistical difference existed between the treatment group and the control group after treatment(P<0.01).Compared with before treatment,urinary levels of IL-6,TGF-β1,and MCP-1 were all down-regulated in the treatment group and the control group after treatment(P<0.01),and the decreasing of IL-6 and TGF-β1 levels was more significant in the treatment group statistically(P<0.05).Conclusions BSHXR could attenuate the albuminuria in patients of chronic nephritis.Its mechanism might be possibly correlated with its down-regulation of IL-6,TGF-β1 and MCP-1 levels.

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