采用国际生活质量量表评价中医药治疗老年晚期非小细胞肺癌的疗效

Assessment of Therapeutic Efficacy on Treating Advanced Non-small Cell Lung Cancer in the Aged by Chinese Medicine Adopting the International Questionnaire of Quality of Life

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DOI：

中文关键词: 中医药疗法晚期非小细胞肺癌老年患者生活质量

英文关键词:Chinese medicine therapy advanced non-small cell lung cancer aged patient quality of life

基金项目:民政部中国老年学学会科研课题(No.2008-47-2-41)

作者	单位
游捷	上海中医药大学附属龙华医院肿瘤三科
韩宝惠	上海交通大学附属胸科医院肺内科
单孟俊	上海中医药大学附属龙华医院肿瘤三科

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中文摘要:

目的采用国际生活质量量表评价中医药治疗老年晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)的疗效。方法将91例老年晚期NSCLC患者随机分成中医组(31例)、化疗组(30例)及中医加化疗组(30例)。中医组采用中药汤剂口服加中药注射剂静脉滴注治疗方法;化疗组单纯接受化疗方案治疗;中医加化疗组采用化疗方案治疗的同时服用中药汤剂,28天为1个周期,均治疗2个周期。分别于治疗前、第2个治疗周期的第10天及第28天采用欧洲癌症研究与治疗组织肺癌生活质量量表(EORTC QLQ-LC43)进行评价。结果经2个周期治疗后,中医组和中医加化疗组患者躯体功能、角色功能、情绪功能、社会功能及总健康状况领域评分高于化疗组,气促、咳嗽、疲倦、失眠、食欲丧失及便秘症状评分低于化疗组,差异均有统计学意义(P<0·05,P<0·01)。结论中医药治疗可减轻老年晚期NSCLC患者的临床症状,改善患者生活质量。

英文摘要:

Objective To assess the therapeutic efficacy of treating advanced non-small cell lung cancer(NSCLC) in the aged by Chinese medicine(CM) adopting the international questionnaire of quality of life(QOL).Methods 91 aged patients with advanced NSCLC were randomly assigned to three groups.There were 31 in the CM group(Group Ⅰ),30 in the chemotherapy group(Group Ⅱ),and 30 in the CM and chemotherapy combination group(Group Ⅲ).Oral administration of CM decoction and intravenous dripping of Chinese patent medicine was given to those in Group Ⅰ.Patients in Group Ⅱ received chemotherapeutic protocol alone.Patients in Group Ⅲ received chemotherapeutic protocol while orally taking CM decoction.Twenty-eight days were taken as one therapeutic course,and two courses in total.Assessment was performed using European Organization for Research and Treatment of Lung Cancer Quality of Life Questionnaire LC-43(EORTC QLQ-LC43) before treatment,the 10th day of the second therapeutic course,and the 28th day of the second therapeutic course,respectively.Results After two therapeutic courses of treatment,compared with Group Ⅱ,better effects were obtained in Group Ⅰ and Group Ⅲ in the aspects of the physical function,roles function,emotional functions,social functions,general health state,and short breath,cough,fatigue,insomnia,poor appetite,and constipation(P<0.05,P<0.01).Conclusions CM therapy could relieve the clinical symptoms of aged patients with advanced NSCLC and improve their QOL.

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