| 杨丽丽,任永平,刘义国,刘陕西,李飞,贺乐琴,高芳.中西药联用防治500例血友病出血的临床研究[J].中国中西医结合杂志,2011,31(7):888-891 |
| 中西药联用防治500例血友病出血的临床研究 |
| Clinical Study of Combination of Chinese Medicine and Western Medicine in Treatment of 500 Patients with Hemophilia Hemorrhage |
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| DOI： |
| 中文关键词: 血友病 出血 止血煎剂 止血合剂 安全性 |
| 英文关键词:hemophilia hemorrhage hemostatic apozem hemostatic mixture safety |
| 基金项目:中日血友病研究中心科研基金项目(No.2010002) |
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| 中文摘要: |
| 目的研究中药止血煎剂联合西药止血合剂防治血友病出血的效果及其安全性。方法随机选取2005年2月—2010年7月陕西医大血液病研究院接诊的血友病患者500例,对其中332例出血者和451例需预防外科手术出血者,在不用凝血因子Ⅷ、Ⅸ等血液制品条件下,采用中药止血煎剂口服与西药止血合剂静脉滴注防治出血,连续治疗3周,观察止血时间、出血吸收(治愈)时间及其安全性。结果中西药联用治疗血友病出血患者开放性及闭合性出血的止血时间分别为(0·85±0·83)、(2·69±0·65)h,平均止血时间为(2·00±0·69)h;治愈时间分别为:颅内出血(14·13±6·01)天、肌肉出血(18·18±7·34)天、尿血(8·25±4·69)天、关节腔出血(3·27±1·31)天、皮下血肿(7·16±2·32)天、口鼻腔出血(4·26±1·35)天、脊髓出血(19·15±1·36)天、血肿破溃(50·01±20·91)天。出血治愈率为99·10%(329/332)。预防外科手术出血成功率100%(451/451)。治疗期间无严重不良反应发生。结论中药止血煎剂联合西药止血合剂防治血友病出血效果确切、快速,无并发症及不良反应,可作为防治血友病出血的首选方案。 |
| 英文摘要: |
| Objective To study the effect and safety of haemostatic apozem combined with haemostatic mixture on hemophilia hemorrhage.Methods Five hundred hemophilia patients were randomly recruited from Shaanxi Yida Hematology Institute from February 2005 to July 2010.Under the condition of using no blood products such as platelet cofactors Ⅷ and Ⅸ,oral administration of haemostatic apozem combined with intravenous dripping of haemostatic mixture were given to 332 hemorrhagic patients and 451 patients in need of surgery for hemorrhagia prevention.The treatment was lasted for three successive weeks.The hemostatic time,hemorrhage absorption(recovery) time,and their safety were observed.Results The hemostatic time for open bleeding and closed bleeding was(0.85± 0.83) h and(2.69±0.65) h respectively.The average hemostatic time was(2.00±0.69) h.The recovery time for different portions was as follows respectively:intra-cranial hemorrhage(14.13±6.01) days;muscular hemorrhage(18.18±7.34) days;hematuria(8.25±4.69) days;arthrorrhage(3.27±1.31) days;ecchymoma(7.16±2.32) days;bleeding of oral and nasal cavities(4.26±1.35) days;intramedullary hemorrhage(19.15±1.36) days;hematoma ulceration(50.01±20.91) days.The hemorrhage recovery ratio was 99.10%(329/332).The success rate of preventing from surgery hemorrhage was 100%(451/451).No severe adverse reaction occurred during the therapeutic course.Conclusions Haemostatic apozem combined with haemostatic mixture was effective and fast in preventing and treating hemophilia hemorrhage,with no complications or adverse reactions.It could be taken as the first choice for prevention and treatment of hemophilia hemorrhage. |
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