颈动脉粥样硬化与高血压病关系的研究

作者	单位
郑关毅	福建医科大学附属协和医院中医科
孙旭东	福建医科大学附属协和医院心内科
李楠	福建医科大学附属协和医院中医科
李金国	福建医科大学附属协和医院心内科
李光稳	福建省南平市第一医院急诊科

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中文摘要:

目的研究颈动脉粥样硬化(carotid atherosclerosis,CAS)与高血压病的关系。方法观察高血压病患者(其中痰瘀证组70例,非痰瘀证组80例)和非高血压病患者(对照组,30例)的颈动脉彩色多普勒超声检查结果,比较各组CAS发生率。结果痰瘀证组及非痰瘀证组的CAS发生率高于对照组,差异有统计学意义(P<0·01),其中痰瘀证组高于非痰瘀证组(P<0·05)。痰瘀证组与非痰瘀证组CAS斑块构成均以硬斑为主,痰瘀证组软斑比例(41·9%)高于非痰瘀证组(11·4%),差异有统计学意义(P<0·05)。各组CAS斑块分布部位比较差异无统计学意义(P>0·05)。痰瘀证组及非痰瘀证组的左、右颈总动脉内径及左、右颈总动脉、左颈内动脉、左椎动脉阻力指数均高于对照组,差异有统计学意义(P<0·05)。结论高血压病常伴有不同程度的CAS,特别是高血压病痰瘀证患者的CAS斑块中软斑比例较高,提示发生脑梗死等靶器官损害的可能性大。

英文摘要:

Objective To study the correlation between carotid atherosclerosis(CAS) and hypertension.Methods Color Doppler ultrasonography data of CAS were observed in 150 hypertension patients [as the hypertension group,including 70 patients in the phlegm-stasis syndrome(PSS) group and 80 in the non-PSS group] and 30 non-hypertension patients(as the control group).The difference of the CAS occurrence was compared among the three groups.Results The incidence of CAS was higher in the PSS group and the non-PSS group than in the control group,showing statistical difference(P<0.01).Of them,it was higher in the PSS group than in the non-PSS group(P<0.05).Hard plaque dominated in the CAS plaque constitution in both the PSS group and the non-PSS group.Of them the soft plaque ratio was higher in the PSS group than in the non-PSS group,showing statistical difference(41.9% vs 11.4%,P<0.05).The CAS plaque distribution positions among the three groups(P>0.05).The inner diameters of the left and right common carotid artery,and the resistant indices of the left and right common carotid artery,the left internal carotid artery,and the left vertebral artery in the PSS group and the non-PSS group were higher than in the control group(P<0.05).Conclusions Hypertension patients are often accompanied with CAS of various degrees.Especially the soft plaque ratio of the CAS plaque was higher in those of PSS,indicating the possibility of target organs damage such as cerebral infarction was higher.

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