潜阳方对高血压肝阳上亢证大鼠相关指标的影响

作者	单位
吴海峰	温州医学院药学院
汤小华	温州医学院药学院
吕圭源	浙江中医药大学药物研究所
陈晓琳	浙江中医药大学药物研究所
陈素红	温州医学院药学院
陈宁	浙江中医药大学药物研究所

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中文摘要:

目的探讨潜阳方对高血压肝阳上亢证候、血压及相关血管调节因子的影响。方法 30只SD大鼠随机分为正常对照组、模型组及潜阳方组,每组10只。采用附子汤加麻黄碱加盐水三因素制备大鼠高血压肝阳上亢证模型。造模同时潜阳方组灌服潜阳方药液,正常对照组与模型组给予蒸馏水,均连续给药28天,每7天测定大鼠面部温度、抓力、收缩压;每14天观察记录大鼠狂躁程度与毛色;末次给药后测定血浆肾素(PR)、血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)、心钠素(ANP)、降钙素相关基因肽(cGRP)。结果与模型组同期比较,潜阳方组大鼠在给药后14～28天面部温度显著降低,给药后21天收缩压明显降低,给药后28天狂躁易怒、毛发干枯症状好转,AngⅡ水平降低,差异均有统计学意义(P<0·05,P<0·01)。结论潜阳方可改善肝阳上亢证大鼠面部烘热、狂躁易怒、毛发干枯等相关症状,降低收缩压。AngⅡ水平降低可能是其作用机制之一。

英文摘要:

Objective To study the effect of Qianyang Recipe(QYR) on the Gan-yang hyperactivity syndrome(GYHS),the blood pressure,and correlated vascular regulatory factors of hypertension rat.Methods Thirty SD rats were randomly divided into the normal control group,the model group,and the QYR group,ten in each.Hypertension rat model of GYHS was prepared using Aconiti Praeparatae Decoction plus ephedrine plus salt water.Rats in the QYR group orally took QYR physic liquor,while distilled water was given to rats in the normal control group and the model group.They were medicated for 28 successive days.The facial temperature,the grip strength,and the systolic pressure were determined once every 7 days.Rats’ irritable degree and feather color were observed and recorded once every 14 days.After the last administration the plasma renin(PR),angiotensinⅡ(AngⅡ),aldosterone(ALD),atrial natriuretic peptide(ANP),calcitonin gene-related peptide(cGRP) were determined.Results Compared with the model group of the same phase,the facial temperature of rats in the QYR group significantly decreased on the 14th,21th and 28th day after administration.The systolic pressure obviously decreased on the 21st day after administration.On the 28th day after administration symptoms such as irritability,dry hair were improved,and the AngⅡ level decreased.There was significant difference in all these changes(P<0.05,P<0.01).Conclusions QYR could relieve GYHS rats’ symptoms such as facial hotness,irritability,dry hair,and so on,and decrease the systolic pressure.Decreased AngⅡ level might be one of its mechanisms.

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