应用代谢组学进行个体化诊疗研究的探讨

代谢组学作为系统生物学研究领域中最为活跃的分支学科之一,近年来发展迅速,成为国内外研究的热点。个体化诊疗这一医疗模式的提出,强调和注重人体内在因素和个体差异在疾病诊疗上的影响。由于代谢组学反映了在基因与环境共同作用下,形成的个体生物体系功能状态的整体特征,为研究个体化诊疗提供了新的思路和研究平台。通过论述代谢组学用于个体差异研究的思路、方法、进展,认为代谢组学技术在个体化诊疗研究的应用中具有广阔的前景,有望取得从理论到实践的重大突破。

英文摘要:

As one of the most active branch disciplines in the systematic biology research field,metabonomics has developed rapidly in recent years and become the research hotspot at home and abroad.The proposal of individualized diagnosis and treatment has emphasized and focused on the effect of internal factors of the human body and individual difference on the diagnosis and treatment of disease.Since metabonomics reflects that under the joint action of genes and the environment,the overall features of individual biological systems and functions states,thus,providing a new train of thought and research platform for studying individualized diagnosis and treatment.Through discussion of the train of thoughts,methods,progress of metabonomics used in studies on individualized difference,we believe that metabonomics technologies have a broad prospect of application in the individualized diagnosis and treatment.It is promising to have significant breakthrough from theory to practice.

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