热疗联合胸腔注射香菇多糖粉针剂治疗肺癌癌性胸水30例临床观察

Clinical Observation of Thermotherapy Combined with Thoracic Injection of Lentinan in Treatment of Cancerous Hydrothorax of Patients with Lung Cancer

免费下载全文查看/发表评论下载PDF阅读器

DOI：

中文关键词: 热疗香菇多糖癌性胸水

英文关键词:thermotherapy lentinan cancerous hydrothorax

基金项目:

作者	单位
赵成	天津中医药大学第一附属医院肿瘤科
李小江	天津中医药大学第一附属医院肿瘤科
贾英杰	天津中医药大学第一附属医院肿瘤科
黄敏娜	天津中医药大学第一附属医院肿瘤科
陈亮	天津中医药大学第一附属医院肿瘤科

摘要点击次数: 1498

全文下载次数: 4

中文摘要:

目的探讨热疗联合胸腔注射香菇多糖粉针剂治疗肺癌癌性胸水的疗效及机制。方法 60例肺癌合并癌性胸水患者随机分为观察组(30例)和对照组(30例),观察组患者经胸腔闭式引流术放尽胸水后,胸腔内注入香菇多糖后进行热疗;对照组患者经胸腔闭式引流术放尽胸水后,单纯胸腔注射香菇多糖治疗。结果对照组胸水改善总有效率为73.3%(22/30),观察组为83.3%(25/30),两组比较差异无统计学意义(P>0.05);两组治疗后KPS评分评价稳定率及体重稳定率比较,治疗组优于对照组,差异有统计学意义(P<0.05);两组治疗前后均未出现血液系统反应及肝、肾功能损害,治疗期间,两组患者仅有少部分出现发热、胸痛、胸闷、皮疹及恶心、呕吐等不良反应,两组比较差异无统计学意义(P>0.05)。治疗后观察组CD3+、CD4+、CD4+/CD8+、NK细胞较治疗前明显上升,CD8+下降(P<0.05);治疗后两组比较,观察组CD3+、CD4+、CD4+/CD8+及NK细胞均较对照组升高,CD8+下降(P<0.05)。结论热疗联合胸腔注射香菇多糖治疗肺癌癌性胸水疗效较好,未见明显不良反应。

英文摘要:

Objective To study the therapeutic effect and mechanism of thermotherapy combined with thoracic injection of lentinan in treatment of cancerous hydrothorax (CH) in patients with lung cancer.Methods Sixty lung cancer patients complicated with CH were randomly assigned to the observation group and the control group,30 in each.CH was released by closed drainage of the thoracic cavity in all patients.Thermotherapy was given to patients in the observation group after lentinan was thoracically injected,while lentinan was thoracically injected to patients in the control group.Results The total effective rate of CH improvement was 73.3% (22/30) in the control group and 83.3% (25/30) in the observation group,showing insignificant difference (P>0.05).The stability rate and the weight stability rate by Karnofsky’s performance scoring in the observation group were superior to those of the control group,showing significant difference (P<0.05).No hematological reaction,hepatic or renal damage occurred before and after treatment in both groups.Fever,thoracalgia,dyspnea,rash,nausea and vomit appeared in few patients of the two groups,showing insignificant difference (P>0.05).CD+3,CD+4,CD+4/CD+8,and NK obviously increased and CD+8 decreased in the observation group after treatment,showing significant difference from those before treatment (P<0.05).Compared with the control group after treatment,CD+3,CD+4,CD+4/CD+8,and NK obviously increased,CD+8 increased in the observation group (P<0.05).Conclusion Thermotherapy combined with thoracic injection of lentinan showed better effect in treatment of CH in patients with lung cancer.No obvious adverse reaction was seen.

关闭