滋癸汤加减治疗肝肾阴虚型多囊卵巢综合征疗效观察

作者	单位
郑春盛	福建中医药大学附属人民医院检验科
叶双	福建中医药大学附属人民医院妇科
林舒	福建中医药大学附属人民医院妇科
李小平	福建中医药大学附属人民医院妇科
陈春梅	福建中医药大学附属人民医院B超室
蔡艺淑	福建中医药大学附属人民医院妇科

摘要点击次数: 1258

全文下载次数: 5

中文摘要:

目的探讨滋癸汤加减对肝肾阴虚型多囊卵巢综合征的临床疗效。方法用随机数字表法将66例肝肾阴虚型多囊卵巢综合征患者分为中药组和西药组,每组33例。中药组口服滋癸汤加减,西药组口服达英-35(Diane-35),3个月为1个疗程。观察两组治疗前、停药后第1、6个月经周期正常率、基础体温(BBT)、卵巢大小、卵泡数及内分泌激素的变化。结果 (1)停药1个月经周期后中药组月经周期正常率为57.58%,西药组为63.64%,两组比较差异无统计学意义(P>0.05);停药6个月经周期后中药组为45.45%,西药组为21.21%,中药组优于西药组(P<0.05)。(2)停药1个月经周期后两组BBT双相率均有所提高,与治疗前比较差异均有统计学意义(P<0.01),但两组间比较差异无统计学意义(P>0.05);停药6个月经周期后中药组BBT双相率为45.45%,西药组为18.18%,中药组优于西药组(P<0.05)。(3)停药1个月经周期后两组双侧卵巢体积均明显缩小(P<0.01),停药6个月经周期后,中药组较治疗前仍明显缩小(P<0.01),西药组恢复到治疗前状态(P>0.05)。(4)停药1个月经周期后两组卵泡数均明显减少(P<0.01),停药6个月经周期后,中药组仍明显减少(P<0.01),西药组恢复到治疗前状态(P>0.05)。(5)停药1个月经周期后两组促黄体激素(LH)、睾酮(T)、LH/促卵泡激素(FSH)比值均较治疗前降低(P<0.01);停药6个月经周期后,中药组仍下降明显(P<0.01),西药组恢复到治疗前水平(P>0.05)。结论滋癸汤加减可有效治疗肝肾阴虚型多囊卵巢综合征,且远期疗效稳定、持久。

英文摘要:

Objective To study the therapeutic efficacy of Modified Zigui Decoction (MZD) in treatment of polycystic ovary syndrome of Gan-Shen yin deficiency syndrome.Methods 66 polycystic ovary syndrome patients of Gan-Shen yin deficiency syndrome were randomly assigned to the MZD group (Group A) and the Western medicine group (Group B),33 patients in each.Patients in Group A orally took MZD,while those in Group B orally took Diane-35.Their menstrual cycle rate,basal body temperature (BBT),the ovarian size,the number of follicles,and changes of endocrine hormones were observed before treatment,the first menstrual cycle,and the sixth menstrual cycle after treatment.Results (1) The normal rate of one menstrual cycle after stopping taking medicine was 57.58% in Group A and 63.64% in Group B.There was no statistical difference between the two groups (P>0.05).The normal rate of six menstrual cycles after stopping taking medicine was 45.45% in Group A and 21.21% in Group B.The former was superior to the latter,showing statistical difference (P<0.05).(2) The biphasic BBT rates of one menstrual cycle after stopping taking medicine were somewhat elevated in the two groups,better than before treatment respectively (P<0.01).But there was no statistical difference between the two groups (P>0.05).The biphasic BBT rate of six menstrual cycles after stopping taking medicine was 45.45% in Group A and 18.18% in Group B.The former was superior to the latter,showing statistical difference (P<0.05).(3) The bilateral ovarian volume of one menstrual cycle after stopping taking medicine was obviously reduced in both groups (P<0.01).The bilateral ovarian volume of six menstrual cycles after stopping taking medicine was still more reduced than before treatment in Group A (P<0.01),while it returned to the size of before treatment in Group B (P>0.05).(4) The number of follicles of one menstrual cycle after stopping taking medicine was obviously reduced in both groups (P<0.01).The number of follicles of six menstrual cycles after stopping taking medicine was still reduced in Group A (P<0.01),while it returned to the number before treatment in Group B (P>0.05).(5) The luteinizing hormone (LH),testosterone (T),LH/FSH ratio of one menstrual cycle after stopping taking medicine were obviously reduced in both groups (P<0.01).They were still more reduced six menstrual cycles after stopping taking medicine than before treatment in Group A (P<0.01),while they returned to the levels of before treatment in Group B (P>0.05).Conclusions MZD could effectively treat patients with polycystic ovary syndrome of Gan-Shen yin deficiency syndrome.Besides,its long-term efficacy was more stable and lasting.

关闭