黄芪预防儿童哮喘复发的临床研究

作者	单位
张小庄	广东省妇幼保健院儿科
王波	广东省妇幼保健院儿科
罗先琼	广东省妇幼保健院儿科
林英	广东省妇幼保健院儿科
林少勇	广东省妇幼保健院儿科
郭素华	广东省妇幼保健院儿科
陈文娟	广东省妇幼保健院儿科

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中文摘要:

目的研究黄芪对预防哮喘复发临床疗效及对哮喘缓解期Th1/Th2细胞因子的调节作用。方法 90例哮喘缓解期儿童分为黄芪治疗组(黄芪组)、激素治疗组(激素组)和黄芪加激素治疗组(联合组),分别治疗3个月,并选择30名健康儿童为对照组。观察治疗前后最大呼气流量值(PEFR)值的变化及1年随访中哮喘的复发次数;并于治疗前后用ELISA法检测外周血清干扰素γ(IFN-γ)、白细胞介素4(IL-4)含量。结果激素组预防复发的总有效率(73.3%)稍高于黄芪组(66.7%),但差异无统计学意义(P>0.05),联合组总有效率(96.7%)高于激素组和黄芪组,差异有统计学意义(P<0.05)。治疗前3组PEFR、IFN-γ及IL-4比较,差异无统计学意义(P>0.05);3组治疗后与治疗前比较,PEFR、IFN-γ均明显升高(P<0.05),IL-4均明显降低(P<0.05);治疗后联合组与激素组及黄芪组PEFR、IFN-γ、IL-4比较差异有统计学意义(P<0.05)。结论黄芪有预防哮喘复发的作用,黄芪与激素合用,效果更佳。

英文摘要:

Objective To study the clinical efficacy of astragulus’s preventing the recurrence and regulatory effects on Th1/Th2 cytokines in asthmatic children during the remission stage.Methods Ninety asthmatic children during the remission stage were assigned to the astragalus treatment group (Group A),the hormone treatment group (Group B),and the combined group of astragalus and hormone treatment (Group C),30 in each.Thirty healthy children were set up as the control group.The changes of peak expiratory flow rate (PEFR) before and after treatment and the recurrence times during the one-year follow-up were observed.Peripheral serum contents of immunoreactive fibronectin-γ (IFN-γ) and interleukin-4 (IL-4) were detected before and after treatment using ELISA.Results The total effective rate was higher in Group B (73.3%) than in Group A (66.7%),but with no statistical difference between the two groups (P>0.05).It was highest in Group C (96.7%),showing significant difference from the other two groups (P<0.05).The levels of PEFR and IFN-γ significantly increased and IL-4 obviously decreased in the three groups after treatment (P<0.05).No statistical difference of PEFR,IFN-γ,or IL-4 existed in the three groups before treatment (P>0.05).Statistical difference of PEFR,IFN-γ,or IL-4 existed between Group C and Group B after treatment (P<0.05).Conclusions Astragalus played a role in preventing the recurrence of asthma.The combination of astragalus and hormones showed better effects.

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