| 翟笑枫,王双双,李柏.华蟾素注射液对不同体质荷瘤大鼠肿瘤生长的影响[J].中国中西医结合杂志,2011,31(8):1101-1103 |
| 华蟾素注射液对不同体质荷瘤大鼠肿瘤生长的影响 |
| Effect of Cinobufacini Injection on the Tumor Growth of Tumor Bearing Rats of Different Constitutions |
| 免费下载全文 查看/发表评论 下载PDF阅读器 |
| |
| DOI： |
| 中文关键词: 华蟾素注射液 寒热模型 荷瘤模型 药性研究 |
| 英文关键词:Cinobufacini Injection the models of cold syndrome and heat syndrome the tumor bearing model the study of cold and hot properties of Chinese herbs |
| 基金项目:国家自然科学基金资助项目(No.30500669) |
|
| 摘要点击次数: 1345 |
| 全文下载次数: 2 |
| 中文摘要: |
| 目的观察寒、热性药物和寒、热体质对荷瘤大鼠肿瘤生长的影响及华蟾素注射液对不同体质荷瘤大鼠肿瘤生长的影响。方法健康雄性Wistar大鼠80只,随机分为荷瘤对照组、荷瘤热证组、荷瘤寒证组、热证荷瘤组、寒证荷瘤组、荷瘤华蟾素组、热证荷瘤华蟾素组、寒证荷瘤华蟾素组,均在皮下接种肿瘤14天后测量大鼠皮下瘤重量、体积。结果热证荷瘤华蟾素组肿瘤重量及体积[(3.55±1.12)g,(2864.44±1430.51)mm3]和荷瘤华蟾素组肿瘤重量及体积[(4.29±1.14)g,(3397.19±1701.13)mm3]显著低于荷瘤对照组[(6.01±2.45)g,(6218.91±3837.64)mm3]和寒证荷瘤华蟾素组[(6.90±1.57)g,(6168.42±2457.03)mm3],差异有统计学意义(P<0.05),其余各组间比较差异无统计学意义。结论华蟾素对热证体质荷瘤大鼠抑瘤效果较好,提示华蟾素药性可能为寒性,可能适宜用于热证体质荷瘤大鼠。 |
| 英文摘要: |
| Objective To observe effects of cold-and hot-property herbs and effects of hot and cold constitutions on the tumor growth of tumor bearing rats,and to observe the effect of Cinobufacini Injection (CI) on the tumor growth of tumor bearing rats of different constitutions.Methods Eighty healthy male Wistar rats were randomly divided into eight groups,i.e.,the tumor bearing control group,the tumor bearing heat syndrome group,the tumor bearing cold syndrome group,the heat syndrome tumor bearing group,the cold syndrome tumor bearing group,the tumor bearing CI group,the heat syndrome tumor bearing CI group,and the cold syndrome tumor bearing CI group,respectively.The weight and volume of rats’ subcutaneous tumor were measured 14 days after tumor innoculation.Results The weight and volume of tumor in the heat syndrome tumor bearing CI group [(3.55±1.12) g,(2 864.44±1 430.51) mm3 ] and the tumor bearing CI group [(4.29±1.14) g,(3 397.19±1 701.13) mm3 ] were significantly lower than those of the tumor bearing control group [(6.01±2.45) g,(6 218.91±3 837.64) mm3] and the cold syndrome tumor bearing CI group [(6.90±1.57) g,(6 168.42±2 457.03) mm3],showing statistical difference (P<0.05).There was insignificant difference among other groups.Conclusions CI showed better tumor inhibition effects on tumor bearing rats of heat syndrome constitution,which indicated CI was of cold property.It might be possibly used in tumor bearing rats of heat syndrome constitution. |
| 关闭 |
|
|
|
扫描微信二维码，获取更多信息