变通黄芪膏联合西药抗小儿支气管哮喘复发作用研究

目的评价变通黄芪膏联合西药对支气管哮喘(bronchial asthma,BA)复发的干预作用。方法将84例BA患儿随机分为治疗组(43例)和对照组(41例)。发作期予单纯西药治疗,缓解期对照组单纯应用布地奈德加沙丁胺醇(3～8岁每次0.5mL,8～12岁每次0.75mL)雾化吸入,疗程1个月,治疗组服用变通黄芪膏每天1剂,疗程1个月。观察两组治疗前、治疗结束时、停药后6、12个月血清IgG、IgE水平及支气管哮喘复发率。结果治疗组停药后6、12个月复发率分别为9.5%、14.0%,均明显低于对照组(分别为24.4%、34.1%),差异有统计学意义(P<0.05);治疗组患儿血清IgG水平在服药后持续升高,高血清IgE状态得到长期有效的缓解。结论变通黄芪膏对小儿BA具有良好抗复发作用,其作用机制可能与调节患儿的免疫机制有关。

英文摘要:

Objective To assess the intervention of Biantong Huangqi Ointment (BHO) combined with Western medicine (WM) on the recurrence of bronchial asthma (BA). Methods Eighty-four BA children patients were randomly assigned to the treatment group (43 cases) and the control group (41 cases). During the period of onset, patients in the two groups were treated by WM alone. During the remission phase, patients in the treatment group took BHO, one dose daily, while those in the control group were treated with atomized inhalation of Budesonide and Salbutamol (0.5 mL each time for those 3-8 years old; 0.75 mL each time for ≥those 8-12 years old). The therapeutic course for them all was 1 month. The serum levels of IgG and IgE before and after treatment, 6 and 12 months after withdrawal of medication were detected in the two groups, and the recurrence rate of BA observed in the two groups. Results The recurrence rate of the treatment group was obviously lower than that of the control group after withdrawal of medication (9.5% vs 24.4% for 6 months, 14.0% vs 34.1% for 12 months), showing statistical difference between the two groups (P< 0.05). The serum IgG level of children patients in the treatment group increased continuously after medication. The high serum IgE level state obtained long-term and effective relief.Conclusion BHO showed favorable anti-recurrent effect on children′s BA. Its mechanism might be associated with regulating children′s immune system.

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