低分子肝素钙联合银杏达莫注射液预防股骨粗隆间骨折术后下肢深静脉血栓形成临床观察

Clinical Observation of the Low Molecular Weight Heparin Calcium Combined with Yinxing Damo Injection on the Prevention of Deep Venous Thrombosis after the Operation of Intertrochanteric Fracture

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中文关键词: 低分子肝素钙银杏达莫注射液预防深静脉血栓形成

英文关键词:low molecular weight heparin calcium Yinxin Damo Injection prevention deep venous thrombosis

基金项目:

作者	单位
郑加法	大连大学附属中山医院骨科
孙强	大连大学附属中山医院骨科
彭德付	大连大学附属中山医院骨科

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中文摘要:

目的观察低分子肝素钙联合银杏达莫注射液预防股骨粗隆间骨折术后下肢深静脉血栓形成(DVT)的效果。方法 62例股骨粗隆间骨折患者随机分为对照组和联合组,每组各31例。对照组采用低分子肝素钙6000IU每天2次皮下注射;联合组在此基础上加用银杏达莫注射液(20mL,每天1次,静脉滴注)。两组疗程均为10天。比较两组术后DVT发生率、术后引流血量、活化部分凝血活酶时间(APTT)、血浆凝血酶原时间(PT)、血小板计数、术后下肢最大肿胀率。结果对照组5例(16.1%)发生DVT;联合组2例(6.5%)发生DVT,两组比较差异有统计学意义(P<0.05);给药2天后两组患者APTT和PT均缩短(P<0.01),与对照组比较,联合组缩短更明显,差异有统计学意义(P<0.05)。给药10天后对照组患者APTT和PT均较给药前缩短(P<0.01),联合组较给药前延长,与对照组比较,差异有统计学意义(P<0.05);联合组给药10天后血小板计数较给药前升高,且高于对照组,差异有统计学意义(P<0.05),但均在正常范围内。结论低分子肝素钙联合银杏达莫注射液不仅能够降低股骨粗隆间骨折术后DVT的发生率,并能改变血液的髙凝状态,对于预防股骨粗隆间骨折术后下肢深静脉血栓形成具有显著效果。

英文摘要:

Objective To observe the therapeutic effect of the low molecular weight heparin calcium(LMWHC) combined with Yinxin Damo Injection(YDI) on the prevention of deep venous thrombosis(DVT) after the operation of intertrochanteric fracture. Methods Sixty-two patients with intertrochanteric fracture were randomly assigned to the control group and the combined group,31 in each group. Patients in the control group were subcutaneously injected with 6 000 IU LMWHC,twice daily. On this basis of the aforesaid treatment,patients in the combined group were intravenously dripped with YDI at the daily dose of 20 mL,once daily. The treatment lasted for 10 days in both groups. The DVT incidence rate,postoperative drainage amount of blood,activated partial thromboplastin time(APTT) ,plasma prothrombin time(PT) ,platelet count,and the maximal swelling rate of lower limbs after surgery were compared between the two groups after operation. Results In the control group DVT occurred in 5 cases(16.1%) while it occurred in 2 cases(6.5%) in the combined group,showing significant differences(P<0.05) . Both APTT and PT were shortened in the two groups on the 2nd day after medication(P<0.01) . Compared with the control group,it was more obvious in the combined group,showing statistical significance(P<0.05) . Both APTT and PT were shortened in the control group on the 10th day after medication when compared with before treatment(P<0.01) . But they were postponed in the combined group when compared with before medication,showing statistical difference when compared with the control group(P<0.05) . The platelet count increased in the combined group on the 10th day after medication. Besides,it was higher than that in the control group,showing statistical difference(P<0.05) . The platelet counts were in the normal range. Conclusions LMWSC combined with YDI could not only reduce the incidence of DVT after the operation of intertrochanteric fracture,but also change the state of higher blood coagulation. It showed significant effect on preventing DVT after the operation of intertrochanteric fractures.

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