蚓激酶胶囊联合普罗布考片治疗脑梗死患者颈动脉不稳定粥样斑块的疗效观察

Efficacy Observation of Combination of Lumbrukinase Capsule and Probucol Tablet in Treating Cerebral Infarction Patients′ Unstable Atheromatous Plaque of the Carotid Artery

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中文关键词: 蚓激酶胶囊普罗布考片颈动脉不稳定斑块

英文关键词:Lumbrukinase Capsule Probucol Tablet carotid artery unstable plaque

基金项目:

作者	单位
张忠文	武汉市中西医结合医院神经内科
邵卫	武汉市中西医结合医院神经内科
潘晓峰	武汉市中西医结合医院神经内科
陈国华	武汉市中西医结合医院神经内科

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中文摘要:

目的观察蚓激酶胶囊联合普罗布考片对脑梗死患者颈动脉不稳定粥样斑块的影响。方法将150例脑梗死患者采用分层随机抽样法分为普罗布考片治疗组(对照组)和蚓激酶胶囊联合普罗布考片治疗组(治疗组),每组75例。对照组口服普罗布考片0.5g,每天2次;治疗组在口服普罗布考片基础上加用蚓激酶胶囊60万U,每天3次,均治疗12个月。两组治疗前及治疗6、12个月后检测总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、纤维蛋白原(FIB)及颈动脉粥样硬化斑块的变化,同时记录不良事件的发生情况。结果两组治疗6个月后TC、TG、LDL-C较治疗前均明显降低,差异有统计学意义(P<0.05),HDL-C高于治疗前水平,差异无统计学意义。两组治疗后较治疗前FIB水平均有显著下降,且治疗组与对照组比较,差异有统计学意义(P<0.05)。治疗12个月后两组血脂及FIB指标与治疗6个月后比较差异无统计学意义(P>0.05)。而治疗组斑块有效率优于对照组,差异有统计学意义(P<0.01)。治疗期间,治疗组脑血管事件发生率低于对照组(P<0.05),两组均有部分患者出现胃部不适症状。结论蚓激酶胶囊联合普罗布考片能防治动脉硬化,稳定斑块,有效减少缺血性事件的发生,临床使用未增加出血风险,安全有效,值得推广。两组联合用药是否增加消化道副作用还有待进一步观察。

英文摘要:

Objective To observe the effects of combination of Lumbrukinase Capsule(LC) and Probucol Tablet(PT) in treating cerebral infarction(CI) patients′ unstable atheromatous plaque of the carotid artery. Methods 150 patients were randomly assigned to the PT group and the LC group,75 cases in each. Patients in the PT group took 0.5 g PT each time,twice daily. On the basis of PT,patients in the LC group also took 600 thousand U LC,thrice daily. The treatment course was 12 months for all. The serum levels of TC,TG,HDL-C,LDL-C,fibrinogen(FIB) ,and changes of the carotid atherosclerotic plaque were measured before treatment,6 and 12 months after treatment. Meanwhile,adverse events were recorded. Results The serum levels of TC,TG,and LDL-C were all lower 6 months after treatment than before treatment in the two groups,showing statistical significance(P<0.05) . The serum level of HDL-C was higher 6 months after treatment than before treatment in the two groups,showing no statistical significance(P>0.05) . When compared with before treatment in the same group,the serum level of FIB significantly decreased after treatment. Besides,there was statistical difference between the two groups(P<0.05) . There was no statistical difference in the serum levels of blood lipids or FIB between 12-month treatment and 6-month treatment in the same group(P>0.05) . The plaque effective rate in the LC group was superior to that of the PT group,showing statistical significance(P<0.01) . During the treatment period,the occurrence of cerebrovascular event was lower in the LC group than in the PT group(P<0.05) . Partial patients in the two groups had gastric discomfort. Conclusions The combination of LC and PT could prevent and treat arteriosclerosis,stabilize the plaque,effectively lower the occurrence of ischemic events. Its clinical application did not increase the risk of hemorrhage. It was safe and effective,worthy of spreading. It was necessary to further observe whether combination of LC and PT could increase side effects of the digestive tract.

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