武汉地区900例缺血性脑卒中风痰瘀阻型及气虚血瘀型患者危险因素回顾性分析

Retrospective Analysis of Risk Factors in 900 Patients with Ischemic Cerebral Stroke of Wind-Phlegm Collateral Obstruction Syndrome and Qi Deficiency Blood Stasis Syndrome in Wuhan District

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中文关键词: 缺血性脑卒中风痰瘀阻型气虚血瘀型危险因素

英文关键词:ischemic cerebral stroke wind-phlegm collateral obstruction syndrome qi deficiency blood stasis syndrome risk factor

基金项目:湖北省科技攻关计划(No.2007AA301B09-2)

作者	单位
魏丹	华中科技大学同济医学院附属中西医结合医院神经内科
王开欣	华中科技大学同济医学院附属中西医结合医院神经内科
邵卫	华中科技大学同济医学院附属中西医结合医院神经内科
邱昕	华中科技大学同济医学院附属中西医结合医院神经内科
潘宋斌	华中科技大学同济医学院附属中西医结合医院神经内科
陈国华	华中科技大学同济医学院附属中西医结合医院神经内科

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中文摘要:

目的探讨缺血性脑卒中的危险因素与中医风痰瘀阻型和气虚血瘀型的相关性。方法收集缺血性脑卒中风痰瘀阻型和气虚血瘀型患者900例,采用χ2检验及非条件Logistic回归分析法观察这两种证型性别、年龄、发病时间、发病部位、舌质、舌苔、脉象、高血压、糖尿病、既往卒中史、高血脂、红细胞压积、吸烟、饮酒、遗传、血型及并发症等危险因素的差异。结果风痰瘀阻型与气虚血瘀型年龄(χ2=8.2392,P=0.0413)、高血脂(χ2=4.8386,P=0.0278),舌质(χ2=7.9470,P=0.0048)、舌苔(χ2=4.3298,P=0.0375)4个因素比较差异有统计学意义。风痰瘀阻型和气虚血瘀型高血脂、舌质、舌苔相对危险度(OR)比较,差异均有统计学意义,其OR值分别为0.699(P=0.0282)、0.332(P=0.0071)和0.667(P=0.0382)。既往卒中史,并发症和前循环梗死3个因素其OR值分别为3.226(P=0.0314),0.203(P=0.0705)和0.214(P=0.0098)。结论各年龄组气虚血瘀型构成比明显高于风痰瘀阻型,且气虚血瘀型更易发生高血脂、前循环梗死和并发症,年龄、血脂水平、梗死部位、并发症与缺血性脑卒中中医证型关系密切,可为缺血性脑卒中中医辨证分型提供客观量度。

英文摘要:

Objective To analyze the correlation between risk factors and ischemic cerebral stroke of wind-phlegm collateral obstruction syndrome and qi deficiency blood stasis syndrome. Methods Totally 900 patients of the two syndrome types were recruited. Risk factors correlated to ischemic cerebral stroke such as gender,age,time of onset,site of infarction,tongue proper,tongue fur,pulse picture,hypertension,diabetes,past stroke history,hyperlipidemia,hematocrit,smoking,drinking,genetic factor,blood type,complications were analyzed using Chi-square test and non-conditional Logistic regression analysis. Results Statistical significance existed between the two syndrome types in age(χ2=8.2392,P=0.0413) ,hyperlipidemia(χ2=4.8386,P=0.0278) ,tongue proper(χ2=7.9470,P=0.0048) ,and tongue fur(χ2=4.3298,P=0.0375) . Statistical significance existed between the two syndrome types in hyperlipidemia,tongue proper,and tongue fur,and their OR value was 0.699(P=0.0282) ,0.332(P=0.0071) ,and 0.667(P=0.0382) respectively. The OR value of the past stroke history was 3.226(P=0.0314) ,that of complications 0.203(P=0.0705) ,and that of anterior circulation infarction 0.214(P=0.0098) . Conclusions Among different ages groups,the constituent ratio of qi deficiency blood stasis syndrome was obviously higher than that of wind-phlegm collateral obstruction syndrome. Besides,patients of qi deficiency blood stasis syndrome were liable to suffer from hyperlipidemia,anterior circulation infarction,and complications. The age,blood lipid levels,site of infarction,complications are closely correlated with Chinese syndrome types of ischemic cerebral stroke,which can provide objective indices for typing ischemic cerebral stroke.

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