汉族人群肝郁气滞及湿热内蕴型痤疮TLR2 Arg753Gln基因多态性分析

Analysis of the Toll-like Receptor 2 Arg753Gln Gene Polymorphisms of Acne Patients of Gan-depression Induced Qi Stagnation Syndrome and Damp-heat in the Interior Syndrome

免费下载全文查看/发表评论下载PDF阅读器

DOI：

中文关键词: 痤疮肝郁气滞型湿热内蕴型 Toll样受体2 基因多态性

英文关键词:acne Gan-depression induced qi stagnation syndrome damp-heat in the interior syndrome toll-like receptor 2 gene polymorphism

基金项目:湖南省卫生厅科研基金资助项目(No.2006-238);衡阳市科技局科研基金资助项目(No.2008KS003,2010kj04)

作者	单位
田黎明	华中科技大学附属武汉市第一医院皮肤科
王玮蓁	华中科技大学附属武汉市第一医院皮肤科
杨婷	昆明医学院第一附属医院皮肤科
谢红付	中南大学湘雅医院皮肤科
金曌	华中科技大学附属武汉市第一医院皮肤科
胡志敏	华中科技大学附属武汉市第一医院皮肤科
程杨	华中科技大学附属武汉市第一医院皮肤科
胡耀华	南华大学南华医院
彭圆	湖北中医药大学

摘要点击次数: 1271

全文下载次数: 6

中文摘要:

目的探讨汉族人群肝郁气滞及湿热内蕴型痤疮TLR2 Arg753Gln基因多态性,为其发病遗传学研究奠定基础。方法采用PCR-RFLP技术检测75例湿热内蕴型痤疮、87例肝郁气滞型痤疮以及70名健康对照组的TLR2 Arg753Gln基因型分布以及等位基因的频率。结果 Arg/Gln+Gln/Gln基因型于肝郁气滞型为26.44%(23/87)、湿热内蕴型为41.33%(31/75)、健康对照组为12.86%(9/70),各组间比较差异均有统计学意义(P<0.05)。结论 TLR2 Arg753Gln基因多态性中等位基因753Gln的存在,增加了汉族人群肝郁气滞及湿热内蕴型痤疮的发病风险。

英文摘要:

Objective To study the toll-like receptor 2(TLR2) Arg753Gln gene polymorphisms of acne patients of Gan-depression induced qi stagnation syndrome and damp-heat in the interior syndrome,thus laying the foundation for genetics studies on its occurrence.Methods The distribution and the frequency of allelic genes were studied in 75 acne patients of damp-heat in the interior syndrome,and 87 acne patients with Gan-depression induced qi stagnation syndrome,as well as 70 healthy subjects(as the normal control group) using polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) technique.Results There was significant difference in the frequency of the genotype Arg/Gln+Gln/Gln in the TLR2 Arg753Gln genetic polymorphisms [26.44%(23/87) in Gan-depression induced qi stagnation syndrome,41.33%(31/75) in damp-heat in the interior syndrome,and 12.86%(9/70) in the normal control group](P<0.05).Conclusion The existence of 753Gln allele in the Arg753Gln of TLR2 increased the onset risk of acne patients of Gan-depression induced qi stagnation syndrome and damp-heat in the interior syndrome.

关闭