温肾化痰方对早中期脾肾阳虚型慢性肾功能不全患者肾功能及血脂的影响

Effects of Wenshen Huatan Recipe on the Renal Function and the Blood Lipids of Patients with Early-middle Stage Chronic Renal Insufficiency of Pi-Shen Yang Deficiency

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DOI：

中文关键词: 温肾化痰方慢性肾功能不全脾肾阳虚

英文关键词:Wenshen Huatan Recipe chronic renal insufficiency Pi-Shen yang deficiency

基金项目:

作者	单位
戴芹	上海市浦东新区浦南医院肾内科
王怡	上海中医药大学附属岳阳医院
曲晓璐	上海市浦东新区浦南医院肾内科

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中文摘要:

目的通过观察温肾化痰方治疗早中期脾肾阳虚型慢性肾功能不全(chronic renal insufficiency,CRI)患者的临床疗效,探讨从痰浊论治本病的临床有效性。方法选择90例早中期脾肾阳虚型CRI的患者,按2:1随机分为治疗组60例和对照组30例。两组患者在接受一般处理及对症治疗的同时,治疗组加用温肾化痰方治疗,疗程6个月。观察两组治疗6个月后的总有效率、中医证候积分、肾功能[血肌酐(SCr)、血尿素氮(BUN)]、内生肌酐清除率(CCr)、血清胱抑素-C(Cys-C)、血脂[总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]变化及不良反应。结果治疗组治疗6个月后的总有效率为70.0%(42/60),明显优于对照组43.3%(13/30,P<0.05),治疗组中医证候积分下降明显,两组比较差异有统计学意义(P<0.01)。治疗组在降低SCr、BUN、Cys-C及LDL-C,升高CCr方面均优于对照组(P<0.05)。结论温肾化痰方可延缓慢性肾功能衰竭的进程,改善脂质代谢,提示从痰论治早中期CRI确有一定的临床疗效。

英文摘要:

Objective To study the clinical effectiveness of Wenshen Huatan Recipe(WHR) in treating early-middle stage chronic renal insufficiency(CRI) of Pi-Shen yang deficiency syndrome(PSYDS).Methods Ninety early-middle stage CRI patients of PSYDS were recruited and randomly assigned to the treated group(60 cases) and the control group(30 cases) in the ratio of 2:1.All patients received conventional and symptomatic treatment,but those in the treated group received WHR additionally.The observation was lasted for six months.The total efficacy,the Chinese medicine syndrome integral,and indices of the renal functions [including serum creatinine(SCr),blood urea nitrogen(BUN),creatinine clearance(CCr),serum cystatin C(Cys-C)],blood lipids [total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),and low density lipoprotein cholesterol(LDL-C)],as well as adverse reactions were observed before and after treatment.Results After six months of treatment,the total effective rate in treated group was 70.0%(42/60),which was obviously higher than that in the control group [43.3%(13/30),P<0.05].The Chinese medicine symptoms in the treated group were obviously improved,showing statistical difference between the two groups(P<0.01).Better effects in lowering SCr,BUN,Cys-C,and LDL-C and increasing CCr were obtained in the treated group than in the control group(P<0.05).Conclusion WHR could postpone the progression of CRI,improve the lipid metabolism,indicating certain therapeutic efficacy could be obtained in treating early-middle stage CRI from sputum theory.

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