从血管老化角度探讨动脉粥样硬化中医防治策略

作者	单位
申定珠	上海市中医老年医学研究所
陈川	上海市中医老年医学研究所
迟惠英	上海市中医老年医学研究所
赵红彬	上海市中医老年医学研究所

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中文摘要:

动脉粥样硬化是随增龄不断增长、以中老年人为主要发病人群的慢性退行性疾病,抗血管细胞老化正逐渐成为动脉粥样硬化治疗的新策略。动脉粥样硬化演进过程中,内皮细胞更新加快,出现多种诱导血管老化的生物学功能紊乱,引起端粒、端粒酶的变化,造成内皮细胞老化及功能异常。在炎症等致病因素与AS斑块形成之间,端粒、端粒酶可能起着关键性的桥梁作用。我们以往工作发现,补肾为主的中药复方在明显改善衰老症状和功能的同时也表现出抑制动脉粥样硬化的显著作用。应积极探讨中医对动脉粥样硬化从肾论治、补肾中药从端粒途径调控动脉粥样硬化血管细胞老化的作用机制,为建立基于血管老化的动脉粥样硬化中医防治策略提供依据。

英文摘要:

Atherosclerosis,a chronic degenerative disease mainly attacks the middle-aged and the aged population as they grow old.Anti-angiocellular aging has gradually become a new strategy for atherosclerosis.In the process of atherosclerosis developing,endothelial cell renewing is speeding.Various biological function disorders that induce blood vessel aging emerge,which leads to changes of the telomere and telomerase,resulting in aged endothelial cells and dysfunction.Telomere and telomerase may play key roles in the etiological factors such as inflammation and AS plaque.In our previous work we have found that Chinese compounds wiht Shen invigorating effects could not only obviously ameliorate the symptoms and functions of the senility,but also show significant effects on restraining artherosclerosis.We should actively study the mechanisms of Chinese medicine for treating atherosclerosis from Shen,and the mechanisms of Shen invigorating compounds for regulating angiocellular aging through the telomere pathway,thus providing evidence for establishing vascular cell aging based atherosclerosis prevention and treatment strategies by Chinese medicine.

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