腧穴热敏化艾灸对慢性腹泻脾肾亏虚证患者胃泌素及胃动素的影响

作者	单位
何凌	江西中医学院附属医院消化科
姜国平	江西中医学院附属医院消化科
刘华	江西中医学院附属医院消化科
杨建安	江西中医学院附属医院检验科

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中文摘要:

目的观察腧穴热敏化艾灸治疗慢性腹泻临床疗效及其对血清胃泌素(gastrin,GAS)、血浆胃动素(motilin,MTL)水平的影响。方法选择中医辨证为脾肾亏虚型慢性腹泻患者60例,随机分为腧穴热敏化艾灸治疗组(治疗组,腧穴热敏化艾灸,每天1次)及肠泰合剂治疗组(对照组,口服肠泰口服液,每次10mL,每天3次),两组均治疗4周。另选取20名体检健康者作为健康对照组(健康组)。采用放射免疫法测定各组治疗前后血清GAS及血浆MTL水平。治疗结束后观察两组临床痊愈、显效、有效、无效例数及总有效率。结果治疗前两个患者组血清GAS水平均低于健康组,血浆MTL水平均高于健康组,差异均有统计学意义(P<0.05),患者组症状积分与健康组比较,差异无统计学意义(P>0.05)。治疗后两个患者组血清GAS水平升高,血浆MTL水平及症状积分降低,与本组治疗前比较,差异有统计学意义(P<0.05,P<0.01),治疗组治疗后症状积分低于对照组,差异有统计学意义(P<0.05),两组GAS及MTL水平比较,差异无统计学意义(P>0.05)。治疗组临床症状总有效率(93.3%)高于对照组(73.3%),差异有统计学意义(P<0.05)。结论腧穴热敏化艾灸治疗脾肾亏虚型慢性腹泻患者疗效较好,能调节患者血清GAS和血浆MTL水平,改善患者临床症状。

英文摘要:

Objective To observe the therapeutic efficacy of acupoint heat-sensitization moxibustion on chronic diarrhea patients as well as its effects on the levels of gastrointestinal neurotic mediators such as serum gastrin(GAS) and plasma motilin(MTL).Methods Sixty chronic diarrhea patients of Pi-Shen deficiency syndrome were randomly assigned to Group A(30 cases,treated with acupoint heat-sensitization moxibustion,once daily) and Group B(30 cases,treated with Changtai Oral Liquid,10 mL each time,three times daily).The therapeutic course was 4 weeks.Another 20 healthy volunteers were recruited as the health control group.The levels of serum GAS and plasma MTL were detected using radioimmunoassay before and after treatment.The cured rate,the markedly effective case,the effective case,the ineffective case,and the total effective rate were calculated by the end of the treatment.Results Before treatment the serum GAS level was lower and the plasma MTL level higher in the two patient groups than in the health control group with statistical difference(P<0.05).There was no statistical difference in the symptom integral between the two patient groups and the health control group(P>0.05).After treatment the serum GAS level increased,the plasma MTL level and the symptom integral decreased in the two patient groups,showing statistical difference when compared with the same group before treatment(P<0.05,P<0.01).After treatment the symptom integral was lower in the treatment group than in the control group with statistical difference(P<0.05).There was no statistical difference in the GAS and MTL levels between the two patient groups(P>0.05).The total effective rate for clinical symptoms was significantly higher in Group A than in Group B with statistical difference(93.3% vs 73.3%,P<0.05).Conclusions The therapy of acupoint heat-sensitization moxibustion was effective for chronic diarrhea patients of Pi-Shen deficiency syndrome.It could regulate the levels of serum GAS and plasma MTL and improve the patients’ clinical symptoms.

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