复方丹参注射液治疗早发型重度子痫前期患者临床疗效评价

作者	单位
童重新	河北省儿童医院妇产科
邢小芬	河北省儿童医院妇产科
乔书花	河北省儿童医院妇产科
刘琳	河北省儿童医院妇产科

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中文摘要:

目的观察复方丹参注射液治疗早发型重度子痫前期患者的临床效果。方法选择孕龄26～34周重度子痫前期患者120例,自愿应用复方丹参注射液治疗患者60例为治疗组,同期住院患者60例为对照组,对照组给予常规治疗,治疗组在常规治疗基础上加用复方丹参注射液16mL加入5%葡萄糖注射液250mL静脉滴注,每天1次,两组连续治疗7天。比较两组治疗前后D-二聚体(D-dimer,DD)、纤维蛋白原(fibrinogen,Fg)、血细胞比容(hematocrit,HCT)、组织纤溶酶原激活剂(tissue plasminogen activator,t-PA)、组织纤溶酶原激活剂抑制物-1(plasminogen activator inhibitor-1,PAI-1)、平均动脉压(mean arterial pressure,MAP)、24h尿量(24hurine volume,24hUV)、24h尿蛋白定量(24h urine protein,24hUP)、血清甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)、载脂蛋白A1(apolipoprotein A1,apoA1)、载脂蛋白B(apolipoproteinB,apoB)、脐动脉收缩期与舒张期血流速度比值(S/D)及羊水指数(amniotic fluid index,AFI),比较两组治疗后胎盘重量(placenta weight,PW),新生儿体重(neonatal weight,NW),1min Apgar评分。结果两组治疗前DD、Fg、HCT、t-PA、PAI-1、MAP、24hUV、24hUP、TC、TG、HDL-C、LDL-C、,apoA1、apoB、S/D、AFI比较,差异均无统计学意义(P>0.05)。治疗组治疗后Fg、PAI-1、24hUP较治疗前及对照组同期降低,24hUV、AFI升高,且高于对照组同期,差异均有统计学意义(P<0.05,P<0.01)。对照组治疗后24hUV升高,24hUP降低(P<0.01),其余指标未见改善(P>0.05)。治疗组PW、NW、1min Apgar评分≥7分例数均高于对照组,差异均有统计学意义(P<0.05)。结论复方丹参注射液有助于改善早发型重度子痫前期患者机体高凝状态,保护母体重要器官,改善新生儿预后。

英文摘要:

Objective To analyze the clinical effectiveness of Compound Danshen Injection(CDI) in treating patients with early onset severe preeclampsia.Methods One hundred and twenty patients with early onset severe preeclampsia were recruited and their gestational age ranged between 26 and 34 weeks.Sixty patients who volunteered to receive CDI were recruited as the treatment group,while 60 inpatients were recruited as the control group at the same time period.The routine therapy was given to those in the control group.CDI was intravenously dripped to those in the treatment group additionally by adding in 250 mL 5% glucose injection,once daily.The treatment for all lasted for 7 successive days.The D-dimer(DD),fibrinogen(Fg),hematocrit(HCT),tissue plasminogen activator(t-PA),plasminogen activator inhibitor-1(PAI-1),mean arterial pressure(MAP),24 h urine volume(UV),24 h urine protein(24 hUP),triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),apolipoprotein A(apoA1),apolipoprotein B(apoB),umbilical arterial S/D ratio(S/D),and amniotic fluid index(AFI) were compared between the two groups before and after treatment.The placenta weight(PW),neonatal weight(NW),1 min Apgar scoring were compared between the two groups before and after treatment.ResultsThere was no difference in DD,Fg,HCT,t-PA,PAI-1,MAP,UV,24 hUP,TC,TG,HDL-C,LDL-C,apoA1,apoB,S/D,or AFI between the two groups before treatment(P>0.05).In the treatment group PAI-1,Fg,and 24 hUP de-creased more after treatment,and they were lower than those of the control group after treatment.The UV and AFI increased and they were higher than those of the control group after treatment with statistical difference shown(P<0.05,P<0.01).In the control group the UV increased and 24 hUP decreased after treatment(P<0.01).There was no improvement in the rest indices(P>0.05).The PW,NW,and 1 min Apgar score≥7 were all higher in the treatment group than in the control group,showing statistical difference(P<0.05).Conclusion CDI was helpful to improve the high condensation state of patients with early onset severe preeclampsia,protect important organs of the mother,and improve the prognosis of neonates.

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