高效抗逆转录病毒治疗艾滋病致血液毒性反应中医证候分析

基金项目:国家科技重大专项“十一五”规划“艾滋病和病毒性肝炎等重大传染病防治”课题项目(No.2008ZX10005-003B);国家中医药管理局中医药重点学科建设项目[No.国中医药发(2009)30号];郑州市科技创新团队建设项目(No.10CXTD140);河南省教育科学“十一五”规划2010年课题项目(No.2010-JKGHAZ-0047)

作者	单位
刘志斌	河南中医学院第一附属医院艾滋病研究中心
陈秀敏	河南中医学院第一附属医院艾滋病研究中心
金艳涛	河南中医学院第一附属医院艾滋病研究中心
郭会军	河南中医学院第一附属医院艾滋病研究中心
蒋自强	河南中医学院第一附属医院艾滋病研究中心

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中文摘要:

目的了解高效抗逆转录病毒治疗(highly active antiretroviral therapy,HAART)艾滋病致血液毒性反应的主要证候特点及差异。方法采用横断面调查的方法,收集HAART治疗后出现血液毒性反应的216例患者四诊信息,归纳证候学特点并分析其差异。结果 216例中主要中医证候为气血两虚证(142例,占65.7%)和脾肾阳虚证(74例,占34.3%);气血两虚证中医症状积分明显低于脾肾阳虚证(P<0.05);气血两虚证组CD4+T细胞计数高于脾肾阳虚证组(P>0.05),两证患者血清病毒载量比较,差异无统计学意义(P>0.05)。气血两虚证组患者生活质量较脾肾阳虚证者高,但差异无统计学意义(P>0.05)。结论 HAART致血液毒性反应的主要证候有气血两虚证和脾肾阳虚证,气血两虚证病情相对较轻,不同证候患者生活质量、CD4+T细胞及病毒载量差别不明显。

英文摘要:

Objective To investigate the main features of Chinese medicine(CM) syndromes and differences of hematotoxicity reaction induced by highly active antiretroviral therapy.Methods The information of CM four diagnostic methods was collected by cross-sectional study.Their syndrome features were summed up and their differences were analyzed.Results Of the 216 patients,the main syndromes were qi-blood deficiency syndrome(142 cases,accounting for 65.7%) and Pi-Shen yang deficiency syndrome(74 cases,accounting for 34.3%).The score of qi-blood deficiency syndrome was obviously lower than that of Pi-Shen yang deficiency syndrome(P<0.05).The count of CD+4 T cells was higher in qi-blood deficiency syndrome than in Pi-Shen yang deficiency syndrome.There was no statistical difference in the serum viral load between the two groups(P>0.05).The quality of life was higher in qi-blood deficiency syndrome than in Pi-Shen yang deficiency syndrome,but with no statistical difference(P>0.05).Conclusions Qi-blood deficiency syndrome and Pi-Shen yang deficiency syndrome were main syndromes of hematotoxicity reaction induced by HAART.The pathogenic condition of qi-blood deficiency syndrome patients was milder.There was no obvious difference in the quality of life,CD+4 T cells,and the viral loads between two syndromes.

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