| 于莎,匡延平,齐聪.中医预培其损序贯疗法对胚胎反复移植失败患者新鲜周期相关指标的影响[J].中国中西医结合杂志,2012,32(6):763-765 |
| 中医预培其损序贯疗法对胚胎反复移植失败患者新鲜周期相关指标的影响 |
| Effects of Yupei Qisun Sequential Method of Chinese Medicine on Correlated Indices of Repeated Implantation Failure Patients in the Fresh Cycle |
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| DOI： |
| 中文关键词: 试管婴儿 预培其损 序贯疗法 胚胎数量 优胚数量 |
| 英文关键词:in vitro fertilization and embryo transfer Yupei Qisun sequential method the number of embryo the number of hig |
| 基金项目:上海市重点学科课题(No.S30303) |
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| 中文摘要: |
| 目的探讨中医(补肾健脾)预培其损序贯疗法对胚胎反复移植失败(repeated implantation fail-ure,RIF)患者新鲜周期相关指标的影响。方法将既往行体外受精-胚胎移植(in virto fertilization and em-bryo transfer,IVF-ET)或卵母细胞单精子显微注射(intracytoplasmic sperm injection,ICSI)失败3次及以上的患者,行新鲜取卵/移植周期共60例,分为治疗组(中药结合IVF/ICSI)与对照组(单纯IVF/ICSI),每组30例,比较两组外源性促性腺激素(gonadotropin,Gn)用量、超排卵(controlled ovarian hyperstimulation,COH)时间、移植日子宫内膜厚度、获得卵数、受精数、胚胎数、优质胚胎数、妊娠率及种植率等各项指标的差异。结果治疗组单周期人均获得胚胎(7.5±4.9)个,优质胚胎(5.1±3.8)个,两者较对照组(5.1±3.2,3.2±1.8)均明显升高,差异均有统计学意义(P<0.05)。两组在Gn用量、COH天数、移植日子宫内膜厚度、获得卵数、受精数、妊娠率及种植率方面比较,差异均无统计学意义(P>0.05)。结论中医预培其损序贯疗法结合超排卵有利于胚胎数量和质量的双重提高,有望增加RIF患者的累计妊娠率。 |
| 英文摘要: |
| Objective To study the clinical effects of Yupei Qisun Sequential Method(YQSM,by Shen supplementing and Pi invigorating) of Chinese medicine on correlated indices of repeated implantation failure patients in the fresh cycle.Methods Sixty patients with more than three failure cycles of in virto fertilization and embryo transfer(IVF-ET) or intracytoplasmic sperm injection(ICSI) were recruited.They were assigned to the treatment group(treated by IVF/ICSI and Chinese medicine) and the control group(treated by IVF/ICSI alone),30 in each group.The total dose of gonadotropin(Gn),the days of controlled ovary hyperstimulation(COH),the thickness of endometrium on the day of embryo transplantation,the number of retrieved oocytes,the fertilization number,the embryo number,the high quality embryo number,the pregnancy rate,and the implantation rate were compared.Results In the treatment group the numbers of embryo and high quality embryo were 7.5±4.9 and 5.1±3.2 respectively,which were both higher than those of the control group with significant difference(5.1±3.2,3.2±1.8;P<0.05).No significant difference existed in aspects of the total numbers of Gn,the days of COH,the thickness of endometrium on the day of embryo transplantation,the numbers of retrieved oocytes,the fertilization number,the pregnancy rate,and the implantation rate between the two groups(P>0.05).Conclusion YQSM combined with COH could improve the quantity and the quality of embryos,which was promising to increase the accumulative pregnancy rate of RIF patients. |
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