中医药干预人类免疫缺陷病毒耐药的机遇和挑战

作者	单位
王丹妮	河南中医学院第一附属医院艾滋病临床研究中心
姜枫	河南中医学院第一附属医院艾滋病临床研究中心
张晓伟	河南中医学院第一附属医院艾滋病临床研究中心
郭会军	河南中医学院第一附属医院艾滋病临床研究中心

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中文摘要:

艾滋病严重威胁着人类的健康,虽然高效抗逆转录病毒疗法(highly active anti-retroviral therapy,HAART)的使用使艾滋病的病情进展得到了明显遏制,但是逐年增加的人类免疫缺陷病毒(HIV)耐药问题凸显,影响HAART临床效果甚至导致治疗失败。本文通过对HIV生物学特性、HIV耐药原因、发生率、易发人群、突变位点等研究回顾,从疗程长而可供更换药物缺少、对所有服药者耐药监测和检测仍以更换药物为结局的不可行性、中药干预其他耐药的经验及临床试验中药干预HIV耐药显示出较好的苗头,提出目前国情下是中药干预HIV耐药的大好时机,同时也提出了诸多困难和挑战。希望通过中医药干预能最大限度减少和延缓耐药性的产生,解决我国目前艾滋病防治亟待解决的重大问题。

英文摘要:

AIDS is a serious threat to the human health.Although highly active anti-retroviral therapy(HAART) has obviously prohibited the progress of AIDS,a yearly increasing problems of human immunodeficiency virus(HIV) drug resistance have arousing more attention,affecting the clinical efficacy of HAART,and even resulting in treatment failure.We are lack of exchangeable medicines,while the therapeutic course of AIDS treatment is longer.It is not feasible to monitor and detect the drug resistance of medicine takers by taking the exchangeable medicines as the outcome.Better indications have been obtained by combining the experiences for Chinese medicine and pharmacy(CMP) intervention and CMP’s intervening HIV drug resistance by clinical trails.Based on retrospective studies on the HIV biological features,reasons for HIV drug resistance,the occurrence,the predisposing population,and the mutation sites,the authors addressed it is a good opportunity for CMP in intervening HIV drug resistance at present situation in China.Meanwhile,the authors also raised too much difficulties and challenges.We hope CMP’s intervention can minimize and delay the generation of drug resistance to the utmost,solve key problems in HIV/AIDS prevention and control in China.

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