复方玄驹胶囊联合克罗米芬治疗肾阳虚型排卵障碍性不孕症的临床观察

Clinical Observation on Combination of Compound Xuanju Capsule and Clomiphene Citrate in Treating Ovulatory Dysfunctional Infertility Patients of Shen-yang Deficiency

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DOI：

中文关键词: 排卵功能障碍肾阳虚复方玄驹胶囊克罗米芬

英文关键词:ovulatory dysfunctional infertility Shen-yang deficiency Compound Xuanju Capsule clomiphene citrate

基金项目:

作者	单位
马科	皖南医学院弋矶山医院生殖医学研究所
余小英	皖南医学院弋矶山医院生殖医学研究所
彭弋峰	皖南医学院弋矶山医院生殖医学研究所

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中文摘要:

目的观察复方玄驹胶囊联合克罗米芬对肾阳虚型排卵障碍性不孕症的临床疗效。方法将87 例肾阳虚型排卵障碍性不孕症患者随机分为两组: 观察组 44 例,给予复方玄驹胶囊联合克罗米芬治疗;对照组 43 例,单纯给予克罗米芬治疗。观察两组患者治疗后的临床症状、宫颈黏液、子宫内膜厚度、卵泡质量、排卵情况及妊娠率等指标。结果在改善患者中医肾阳虚证候方面,观察组、对照组有效率分别为86. 4% ( 38 /44) 、25. 6% ( 11 /43) ,观察组明显优于对照组( P < 0. 01) ; 治疗后观察组宫颈黏液、子宫内膜厚度和妊娠率均优于对照组( P <0. 05) ; 两组排卵率、成熟卵泡数比较,差异无统计学意义( P > 0. 05) 。结论复方玄驹胶囊联合克罗米芬治疗肾阳虚型排卵障碍性不孕症,可以减少克罗米芬抗雌激素样作用对子宫内膜的不良影响,增加内膜厚度,有利于妊娠。

英文摘要:

Objective To explore the therapeutic efficacy of combination of Compound Xuanju Capsule(CXC) and clomiphene citrate(CC) for ovulatory dysfunctional infertility(ODI) patients of Shen-yang deficiency syndrome(SYDS).Methods Totally 87 ODI patients of SYDS were randomly assigned to 2 groups,the treatment group(44 cases,treated with CXC and CC) and the control group(43 cases,treated with CC alone).The post-treatment clinical symptoms,the cervical mucus,the endometrial thickness,the quality of follicles,the ovulation,and the pregnancy rate,and so on were observed.Results In aspect of improving the patients’ SYDS,the effective rate was 86.4%(38/44) in the treatment group and 25.6%(11/43) in the control group.It was better in the treatment group(P<0.01).After treatment better effects on the cervical mucus,the endometrial thickness,and the pregnancy rate were obtained in the treatment group,showing statistical difference when compared with the control group(P<0.05).There was no statistical difference in the rate of ovulation and mature follicular numbers between the two groups(P>0.05).Conclusion CXC combined CC could ameliorate hypoestrinemia-like effects on the endometrium,increase the endometrial thickness,and be favorable to the pregnancy in treating ODI patients of SYDS.

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