补水柔木方加安宫黄体酮治疗肾虚肝郁型卵巢早衰的临床观察

Clinical Observation on Treatment of Premature Ovarian Failure Patients of Shen Deficiency Gan Stagnation Syndrome by Combination of Bushui Roumu Recipe and Medroxyprogesterone Acetate Tablet

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中文关键词: 补水柔木方安宫黄体酮卵巢早衰肾虚肝郁型

英文关键词:Bushui Roumu Recipe medroxyprogesterone acetate premature ovarian failure Shen deficiency Gan stagnation syndrome

基金项目:

作者	单位
华方方	新乡医学院第一附属医院妇产一科
夏永华	新乡医学院第一附属医院皮肤科
杨君	新乡医学院第一附属医院妇产一科
王慧玲	新乡医学院第一附属医院妇产一科
梁武风	新乡医学院第一附属医院妇产一科

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中文摘要:

目的观察补水柔木方加安宫黄体酮片治疗卵巢早衰的疗效。方法 90例肾虚肝郁型卵巢早衰患者采用随机数字表法分为3组,每组30例。治疗组予补水柔木方加安宫黄体酮,中药组单用补水柔木方,西药组用人工周期法治疗,3组均治疗3个月,观察用药前后月经改善情况、根据改良Kupperman评分标准评定疗效并监测用药前后血清卵泡刺激素(FSH)、黄体生成素(LH)及雌二醇(E2)水平。结果 (1)月经改善方面:治疗组20例治疗期间月经来潮,停药后10例月经正常,其中1例治疗后1个月妊娠。中药组治疗期间6例月经来潮,停药后2例月经正常。西药组26例治疗期间月经来潮,停药后12例月经正常。治疗组在月经改善方面优于中药组(P<0.01),与西药组比较差异无统计学意义(P>0.05);(2)3组改良Kup-perman评分治疗前后比较差异均有统计学意义(P<0.01);治疗组改良Kupperman症状积分总值改善优于中药组及西药组(P<0.01);心悸症状改善治疗组优于中药组和西药组,差异有统计学意义(P<0.05);潮热汗出症状改善治疗组和中药组优于西药组,差异有统计学意义(P<0.05)。(3)3组治疗后血清E2水平均高于治疗前,FSH及LH水平均低于治疗前,治疗前后比较差异均有统计学意义(P<0.01)。治疗组E2改善优于中药组,FSH、LH改善优于西药组(P<0.05)。结论补水柔木方加安宫黄体酮可改善肾虚肝郁型卵巢早衰患者的临床症状、月经情况及血清生殖激素水平。

英文摘要:

Objective To study the therapeutic efficacy of Bushui Roumu Recipe (BRR) combined Medroxyprogesterone Acetate Tablet (MAT) in treating premature ovarian failure (POF). Methods Totally 90 POF patients of Shen deficiency Gan stagnation syndrome were assigned to 3 groups by random number table, 30 in each group. Patients in the treatment group were treated with BRR and MAT, those in the Chinese medicine group were treated with BRR, and those in the Western medicine group were treated with artificial period method. All patients were treated for 3 months. The menstrual improvement was observed before and after treatment. The therapeutic efficacy was assessed using modified Kupperman scoring standard. The serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) were observed before and after treatment. Results(1) In aspect of the menstrual improvement: In the treatment group 20 patients had menstrual onset during the treatment course. Ten had normal menstruation after discontinued medication. Of them one got pregnancy one month after treatment. In the Chinese medicine group 6 patients had menstrual onset during the treatment course. Two had normal menstruation after discontinued medication. In the Western medicine group 26 patients had menstrual onset during the treatment course. Twelve had normal menstruation after discontinued medication. Better effects on the menstrual improvement were obtained in the treatment group than in the Chinese medicine group (P<0.01), but with no statistical difference when compared with the Western medicine group (P>0.05). (2) There was statistical difference in modified Kupperman scores of the 3 groups between before and after treatment (P<0.01). The improvement of total modified Kupperman score was better in the treatment group than in the other two groups (P<0.01). The improvement of palpitation was better in the treatment group than in the other two groups (P<0.05). The improvement of tidal fever and sweat was better in the treatment group and the Chinese medicine group than in the Western medicine group (P<0.05). (3) After treatment all patients′ serum E2 was higher than before treatment, serum levels of FSH and LH were lower than before treatment. Compared preand post-treatment, there was statistical difference (P<0.01). The serum E2 level in the 3 groups was higher after treatment than before treatment with statistical difference (P<0.01). The levels of FSH and LH were lower in the 3 groups after treatment than before treatment with statistical difference (P<0.01). The improvement of E2 was better in the treatment group than in the Chinese medicine group (P<0.05). The improvement of FSH and LH was better in the treatment group than in the Western medicine group (P<0.05). Conclusion Combination of BRR and MAT could improve the clinical symptoms, menstruation, and serum reproductive hormones in POF patients of Shen deficiency Gan stagnation syndrome.

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