扶正健脾汤结合化疗对实体瘤患儿生活质量及生存期的影响

作者	单位
史学	首都医科大学附属北京儿童医院中医科
祝秀丹	首都医科大学附属北京儿童医院肿瘤外科
王焕民	首都医科大学附属北京儿童医院肿瘤外科
田莉	首都医科大学附属北京儿童医院中医科
刘正茂	首都医科大学附属北京儿童医院中医科
郭秀花	首都医科大学公共卫生与家庭医学学院

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中文摘要:

目的观察扶正健脾汤结合化疗对实体瘤患儿生活质量及生存期的影响。方法选择2005年1月—2008年1月北京儿童医院肿瘤科门诊及住院的实体瘤患儿167例,按随机数字表分为治疗组(83例)和对照组(84例)。两组均采用化疗,治疗组于化疗同时加用扶正健脾汤,每次50～100mL,每天2次。化疗后治疗组加用扶正健脾汤化裁。检测两组患儿治疗前、治疗6个月、治疗1年后WBC、Hb、PLT。观察治疗1、2、3年患儿生活质量、3年存活率及死亡患儿的生存期。结果与对照组同期比较,治疗组治疗6个月、1年后WBC、Hb均升高,治疗1年后PLT升高,差异均有统计学意义(P<0.05,P<0.01)。与本组治疗1年后比较,治疗组治疗2、3年后心理功能、全身症状评分降低(P<0.05,P<0.01);与对照组同期比较,治疗组治疗1年后躯体功能、心理功能、全身症状评分降低,治疗2年后躯体功能、心理功能评分降低,治疗3年后心理功能、全身症状评分降低,差异均有统计学意义(P<0.05)。与对照组比较,治疗组死亡例数降低,存活率升高,死亡患儿生存期延长,差异均有统计学意义(P<0.05)。结论扶正健脾汤结合化疗能有效提高实体瘤患儿的生活质量,提高实体瘤患儿的存活率,延长实体瘤患儿的生存期。

英文摘要:

Objective To study the effects of Fuzheng Jianpi Decoction(FJD) combined chemotherapy on the quality of life(QOL) and the survival time of children with solid tumor.Methods Recruited were 167 solid tumor children patients at Department of Tumor,Beijing Children’s Hospital from Jan.2005 to Jan.2008.They were randomly assigned to the treatment group(83 cases) and the control group(84 cases) according to the random digit table.All had chemotherapy.Those in the treatment group additionally took FJD,50-100 mL each time,twice daily.After chemotherapy those in the treatment group took modified FJD.The WBC,Hb,and PLT were detected in all patients before treatment,6 months after treatment,and 1 year after treatment.The 1-,2-,and 3-year QOL,3-year survival rate,and the survival life of dead children patients were observed.Results Compared with the control group of the same period,the 6-month and 1-year WBC and Hb increased,the 1-year PLT increased in the treatment group,showing statistical difference(P<0.05,P<0.01).Compared with 1-year treatment in the treatment group,the 2-and 3-year psychological functions and the general symptoms scores decreased(P<0.05,P<0.01).Compared with the control group of the same period,the 2-and 3-year somatic functions,psychological functions,and the general symptoms scores decreased in the treatment group;the 2-year somatic functions and psychological functions decreased in the treatment group;the 3-year psychological functions and the general symptoms scores decreased in the treatment group,all with statistical difference(all P<0.05).Compared with the control group,the death number decreased,the survival rate increased,the life span of dead children was prolonged in the treatment group,showing statistical difference(P<0.05).Conclusion FJD combined chemotherapy could effectively improve the QOL of solid tumor children patients,elevate their survival rate,and prolong their life spans.

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