102例新疆地区高血压病与西北燥证证型相关性分析

目的分析102例新疆地区高血压病与西北燥证相关性。方法选择102例2009年8—12月和田、吐鲁番、哈密、伊犁、乌鲁木齐5个地区由县级以上医院确诊的高血压病患者作为病例组。另选取新疆地区亚健康者173例作为对照组,比较两组西北燥证发病率及西北燥证积分;对病例组中医证候积分与西北燥证主兼证证候积分作相关性分析及典型相关性分析。结果病例组西北燥证发病率31.37%(32/102),对照组为16.76%(29/102),病例组高于对照组(χ2=7.934,P<0.01)。病例组燥证总积分高于对照组(P<0.05)。其中病例组肺卫孔窍皮肤燥证、心肾阴虚证及脾胃蕴湿证燥证积分高于对照组(P<0.01),尤以心肾阴虚证明显。高血压各类证候与西北燥证主兼各证证候积分均有较强相关性(P<0.01)。其中阴阳两虚证与燥证总积分相关性最强(r=0.864,P<0.01),其次为阴虚阳亢证(r=0.765,P<0.01)。高血压因变量标准典型相关系数阴阳两虚证最高(r=0.5599),自变量脾胃蕴湿证(r=0.4191)最高。结论西北燥证是新疆地区大多数高血压患者的伴随状态,并以心肾阴虚证为突出表现。西北燥证可加重高血压中医证候积分。高血压阴阳两虚证与西北燥证关系最密切。脾胃蕴湿证对高血压证候积分影响最为显著。高血压与西北燥证的关系以阴阳两虚证和脾胃蕴湿证为决定性因素。

英文摘要:

Objective To analyze the correlation between 102 hypertension patients and northwest dryness syndrome(NDS).Methods In the treatment group recruited were 102 hypertension patients from hospitals with the level above the county level in Hotan,Turpan,Hami,Yili,and Urumqi from August to December 2009.Another 173 sub-healthy subjects were recruited as the control group.The incidence rate and the NDS integral were compared between the two groups.The correlation analysis and canonical correlation analysis were performed between Chinese medical integral in the treatment group and main and complicated syndromes integrals of NDS.Results The incidence rate of NDS was 31.37%(32/102) in the treatment group and 16.76%(29/102) in the control group,showing statistical difference(χ2=7.934,P<0.01).The total integral of NDS was higher in the treatment group than in the control group(P<0.05).Of them,the integrals of Fei-orifice obstruction induced dry syndrome(FOOIDS),Xin-Shen yin deficiency syndrome(XSYDS),and Pi-Wei damp accumulation syndrome(PWDAS) were higher in the treatment group than in the control group(P<0.05),with the most obvious shown in XSYDS.Various syndromes of hypertension were strongly correlated with main and complicated syndromes of NDS(P<0.01).Of them,the strongest correlation was shown between yin-yang deficiency syndrome(YYDS) and NDS(r=0.864,P<0.01),followed by yin deficiency and yang hyperactivity syndrome(r=0.765,P<0.01).The standard canonical correlation coefficient was the highest in YYD(r=0.5599) and the independent variable was the highest in PWDAS(r=0.4191).Conclusions DNS was the contaminant state for most hypertension patients in Xinjiang region,with XSYDS as the most outstanding manifestation.DNS could aggravate the Chinese medical integrals of hypertension.YYDS was closestly correlated with DNS.PWDAS showed most significant effects on the syndrome integral of hypertension.YYDS and PWDAS were decisive factors between hypertension and DNS.

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