银杏叶片对轻度认知障碍患者认知功能的影响

作者	单位
董振华	复旦大学附属华东医院中医科
张春燕	同济大学附属东方医院中医科
蒲斌红	上海市枫林街道社区卫生服务中心中医科
赵明星	复旦大学附属华东医院中医科
肖世源	复旦大学附属华东医院中医科
李亚明	复旦大学附属华东医院中医科

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中文摘要:

目的观察银杏叶片对轻度认知障碍(mild congnitive impairment,MCI)患者认知功能的影响。方法选取113例2009年9月—2011年2月就诊于复旦大学附属华东医院中医认知障碍专科门诊(58例)、同济大学附属东方医院中医门诊(34例)及上海市枫林街道社区卫生服务中心(21例)MCI患者,采用随机数字表法分为治疗组(58例)和对照组(55例),两组均给予基础治疗,治疗组在此基础上加服银杏叶片,每次1片,每天3次,连续服用1年。检测两组治疗前、治疗半年及1年的简易精神状态检查(mini-mental state examination,MMSE)积分、画钟试验(clock drawing task,CDT)积分、MMSE疗效、CDT疗效及痴呆转化率。结果两组治疗前MMSE、CDT积分比较,差异无统计学意义(P>0.05)。与本组治疗前比较,治疗组治疗半年及1年各指标均升高,且高于对照组同期,差异均有统计学意义(P<0.01,P<0.05),治疗半年及1年MMSE、CDT积分比较,差异无统计学意义(P>0.05)。治疗组治疗半年及1年MMSE、CDT总有效率(MMSE分别为67.24%、65.52%,CDT分别为62.07%、60.34%)均高于对照组同期(MMSE分别为36.36%、30.91%,CDT分别为34.55%、30.91%),差异均有统计学意义(P<0.01);治疗组两个时间点MMSE、CDT总有效率比较,差异无统计学意义(P>0.05)。治疗组治疗半年及1年痴呆转化率(分别为1.72%、5.17%)均低于对照组同期(分别为9.09%、14.55%),差异均有统计学意义(P<0.05)。结论银杏叶片1年期干预MCI患者,能够较好地改善认知功能,并初步观察到能降低痴呆的转化率。

英文摘要:

Objective To observe the effects of Ginkgo Biloba Tablet(GBT) in treating mild cognitive impairment(MCI).Methods Totally 113 MCI patients including 58 outpatients at the cognitive impairment clinics of Huadong Hospital,34 outpatients at Chinese Medicine Clinics of Dongfang Hoapital,and 21 outpatients at Fenglin Community Health Service Center,were assigned to the control group(55 cases) and the treatment group(58 cases).Basic treatment was given to them all.Those in the treatment group took GBT additionally,1 tablet each time,3 times a day for 12 successive months.The mini-mental state examination(MMSE) integral,clock drawing task(CDT) integral,MMSE efficacy,CDT efficacy,and dementia conversion rate were detected before treatment,half a year after treatment,and one year after treatment.Results There was no significant difference in scores of MMSE and CDT integrals between the two groups before treatment(P>0.05).Compared with before treatment,each score in the treatment group remarkably increased in the treatment group at the 6 months and 12 months after treatment(P<0.01).They were higher than those of the control group at the same time points,showing statistical difference(P<0.01,P<0.05).There was no significant difference in the integrals of MMSE and CDT between the 6 months of treatment and the 12 months of treatment(P>0.05).The total effective rate of MMSE and CDT of the treatment group at the 6 months and 12 months after treatment(MMSE 67.24% and 65.52%;CDT 62.07% and 60.34%) all exceeded those of the control group at the same time points(MMSE 36.36% and 30.91%;CDT 34.55% and 30.91%),showing significant difference(P<0.01).There was no difference in the total effective rate of MMSE and CDT of the treatment group between the two time points(P>0.05).The dementia conversion rates at the 6 months and 12 months after treatment(1.72% and 5.17%) were lower in the treatment group than in the control group(9.09% and 14.55%),showing statistical difference(P<0.05).Conclusions One-year GBT could significantly improve the cognitive function of MCI patients.It could also lower the dementia conversion rate.

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