AS易损斑块研究现状与四妙勇安汤疗效探讨

作者	单位
丁义	天津中医药大学研究生院
彭立	天津中医药大学研究生院
吕仕超	天津中医药大学研究生院
张军平	天津中医药大学第一附属医院

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中文摘要:

易损斑块是动脉粥样硬化(atherosclerosis,AS)斑块破裂和血栓形成进而导致急性心血管事件发生的基础。通过分析AS易损斑块的研究现状,明确炎症与血栓是斑块易损的关键环节,白细胞与血小板聚集、内皮细胞黏附及其共同的连接机制——PS/PSGL-1在炎症反应与血栓形成中的作用,从抑制细胞黏附、拮抗炎症反应与血栓形成的角度,探讨四妙勇安汤稳定AS易损斑块的研究思路。

英文摘要:

The vulnerable plaque is the basis for atherosclerosis(AS) plaque rupture and thrombosis,thus further leading to the occurrence of acute cardiovascular events(ACEs).By analyzing the current research situation of atherosclerotic vulnerable plaque,identifying that inflammation and thrombosis are key links in plaque vulnerability,and the roles of white blood cell and platelet aggregation,endothelial cell adhesion and their common connection mechanisms:PS/PSGL-1 in inflammation and the formation of thrombosis.From the viewpoints of inhibiting cell adhesion,fighting against inflammation reaction and thrombosis,the research ideas of Simiao Yongan Decoction in stabilizing atherosclerotic vulnerable plaque were explored.

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