生大黄粉对脑出血术后患者血清补体C3、C4及hs CRP的影响

作者	单位	E-mail
方永军	陕西中医学院临床医学院外科教研室（陕西咸阳712000）	primipara@sohu.com
张毅,柯尊华,周振国,周锋,柏鲁宁

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中文摘要:

目的探讨生大黄粉对高血压脑出血（hypertensive intracerebral hemorrhage， HICH）开颅血肿清除术后患者血清补体C3、C4及超敏C反应蛋白（hypersensitive C reactive protein， hs CRP）含量的影响。方法选择40例陕西中医学院附属医院脑外科2009年7月—2010年3月住院HICH开颅血肿清除术后患者，随机分为治疗组和对照组，每组20例，术后第4天开始两组均给予西医常规治疗；治疗组加用生大黄粉5～10 g溶于40 mL温开水，口服或鼻饲2～3次/天，连续治疗10天。于术后第7、14天采用免疫透射比浊法检测两组血清补体C3、C4含量，采用胶乳增强透射比浊法检测两组血清hs CRP含量，并记录两组斯堪的纳维亚卒中量表（scandinavia stroke scale，SSS）评分。结果与本组术后第4天比较，对照组术后第7天C3、C4含量升高，术后第14天SSS评分升高（P<0.05）；治疗组术后第14天C4、hs CRP含量降低，SSS评分升高（P<0.05）。与本组术后第7天比较，治疗组术后第14天C4、hs CRP含量降低，SSS评分升高（P<0.05）。与对照组同期比较，治疗组术后第7天C3、C4含量降低，术后第14天C3、C4、hs-CRP含量降低，SSS评分升高（P<0.05）。结论生大黄粉可显著降低HICH术后患者血清补体C3、C4及hs CRP含量，提高临床疗效。

英文摘要:

of Traditional Chinese Medicine from July 2009 to March 2010. They were randomly assigned to the treatment group （20 cases） and the control group （20 cases）. From the 4th day after surgery， all patients received routine Western medical treatment. The rhubarb powder， 5－10 g dissolving in 40 mL warm water， was administered or nasally fed to those in the treatment group， 2－3 times daily for 10 successive days. The contents of serum C3， C4， and hs CRP were detected in the two groups on the 7th day and the 14th day after operation. The serum hs CRP content was detected using latex particle enhanced immunoturbidimetric assay. The Scandinavia Stroke Scale （SSS） scores were recorded in the two groups. Results Compared with the same group on the 4th day after operation， the levels of serum C3 and C4 increased on the 7th day after operation， and SSS score increased on the 14th day after operation in the control group （P<0.05）. The contents of C4 and hs CRP decreased， and the SSS score increased on the 14th day after operation in the treatment group （P<0.05）. Compared with the same group on the 7th day after operation， the contents of C4 and hs-CRP decreased and the SSS score increased on the 14th day after operation in the treatment group （P<0.05）. Compared with the control group at the same time points， the contents of C4 and C3 decreased on the 7th day after operation； the contents of C3， C4， and hs-CRP decreased， and SSS score increased in the treatment group on the 14th day after operation （P<0.05）. Conclusion The rhubarb powder could significantly decrease the serum levels of C3， C4， and hs CRP， and improve the curative effect in patients with HICH after operation.

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