益气祛湿方治疗重症肌无力的临床疗效及其免疫调节作用观察

目的观察益气祛湿方治疗重症肌无力（myasthenia gravis， MG）的疗效及其对患者免疫功能的影响。方法选择2009年1月—2011年6月山东中医药大学附属医院门诊及病房MGⅠ、Ⅱ型患者40例。随机分为治疗组（20例）和对照组（20例）。治疗组给予益气祛湿方，每天1剂，对照组给予溴吡斯的明60 mg，每天3次，疗程均为8周，观察两组临床疗效及治疗前后免疫指标，同时作安全性评价。结果治疗组愈显率75%，总有效率 95%；对照组愈显率45%，总有效率85%，治疗组优于对照组（P<0.05）。与本组治疗前比较，治疗组治疗后IgA、IgG、CD8升高，IgM、CD4、CD4/ CD8降低，差异有统计学意义（P<0.05）；对照组治疗后各指标无明显变化，差异无统计学意义（P>0.05）。与对照组同期比较，治疗组治疗后IgA、IgG、CD8升高，CD4、CD4/CD8降低，差异有统计学意义（P<0.05）。在治疗过程中，对照组有2例患者出现轻度腹泻、恶心、呕吐，而治疗组未发现不良反应。结论益气祛湿方可以明显改善重症肌无力患者临床症状，调节免疫功能，且无明显不良反应。

英文摘要:

Objective To observe the efficacy of Yiqi Qushi Recipe （YQR） in treating myasthenia gravis （MG） patients and its effects on their immune functions. Methods Recruited were 40 type Ⅰ and Ⅱ MG patients from clinics and wards of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from January 2009 to June 2011. They were randomly assigned to the treatment group （20 cases） and the control group （20 cases）. Patients in the treatment group took YQR， one dose daily， while those in the control group took pyridostigmine 60 mg， three times a day. The therapeutic course consisted of eight weeks. The clinical efficacy， immunization indicators before and after treatment were observed. Meanwhile， the safety evaluation was performed. Results The cured and effective rate was 75% and the total effective rate was 95% in the treatment group. They were 45% and 85% in the control group. Better results were obtained in the treatment group. Compared with the same group before treatment， IgA， IgG， and CD8 increased， IgM， CD4， and CD4/CD8 decreased in the treatment group， showing statistical difference （P<0.05）. There was no obvious change in each index of the control group after treatment （P>0.05）. Compared with the control group after treatment， IgA， IgG， and CD8 increased， CD4 and CD4/CD8 decreased in the treatment group， showing statistical difference （P<0.05）. During the course of treatment， mild diarrhea， nausea， and vomit occurred in two patients of the control group， while no adverse reaction occurred in those of the treatment group. Conclusion YQR could significantly improve clinical symptoms of MG patients， regulate their immune functions， with no obvious adverse reaction.

关闭