血必净注射液对多器官功能障碍综合征的临床作用研究

目的观察血必净注射液对多器官功能障碍综合征（MODS）患者的治疗作用及机制研究。方法选择76例2009年2月—2011年9月浙江省衢化医院ICU MODS患者，随机分为对照组（36例）和治疗组（40例），两组均予常规治疗；治疗组加用生理盐水100 mL加入血必净注射液100 mL，静脉滴注，每天2次，连续治疗7天。观察两组治疗前及治疗后3、7天APACHEⅡ评分、SOFA评分、血清降钙素原（PCT）、肿瘤坏死因子-α（TNF-α）、IL-6和IL-10，比较两组ICU停留时间及28天病死率。结果治疗7天后，治疗组APACHE Ⅱ评分、SOFA评分、TNF-α、IL-6、IL-10及PCT均较治疗前明显下降，与对照组同期比较，差异有统计学意义（P<0.05）；治疗组28天病死率和ICU住院时间、APACHE Ⅱ评分、SOFA评分与对照组比较明显下降，差异有统计学意义（P<0.05）。结论血必净注射液可减少MODS患者ICU住院时间，其机制与调控炎症反应有关。

英文摘要:

Objective To observe the effects and mechanisms of Xuebijing Injection （XI） on multiple organ dysfunction syndrome （MODS） patients. Methods Recruited were 76 MODS patients at ICU， Zhejiang Provincial Quhua Hospital from February 2009 to September 2011. They were randomly assigned to the control group （36 cases） and the treatment group （40 cases）. All patients received conventional treatment. Those in the treatment group were intravenously injected with XI （prepared by adding 100 mL QI in 100 mL normal saline）， twice daily for seven successive days. The APACHE Ⅱ score， SOFA score， serum procalcitonin （PCT）， tumor necrosis factor-α （TNF-α）， interleukin 6 （IL-6） and 10 （IL-10） of the two groups were observed in the two groups before treatment， at 3 days and 7days after treatment. The ICU stay time and the 28-day mortality were compared between the two groups. Results After seven days of treatment， the APACHE Ⅱ score， SOFA score， TNF-α， IL-6， IL-10， and PCT significantly decreased in the treatment group， showing statistical difference when compared with the control group at the same time point （P<0.05）. The 28-day mortality， the ICU stay time， APACHE Ⅱ score， and SOFA score decreased more significantly in the treatment group than in the control group， showing sstatistical difference （P<0.05）. Conclusion XI could significantly reduce the ICU stay time of MODS patients， and its mechanisms might be correlated to regulating inflammatory reactions.

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