丹参多酚酸盐对急性冠脉综合征患者炎症因子影响的相关研究

目的探讨丹参多酚酸盐对急性冠脉综合征（ACS）患者炎症因子［脂联素、抵抗素及C反应蛋白（CRP）］的影响，探讨丹参多酚酸盐治疗对ACS患者治疗的可能机制。方法将83例2011年5月—2012年1月在我院心内科住院的ACS患者随机分为治疗组（42例，常规西药治疗加用丹参多酚酸盐200 mg/d，静脉滴注）及对照组（41例，常规西药治疗），疗程均为14天。观察两组治疗前后脂联素、抵抗素及CRP水平。结果与治疗前比较，两组治疗后血清抵抗素水平及CRP水平显著降低（P<0.05），脂联素水平显著升高（P<0.05），且治疗组抵抗素、CRP的降低幅度及脂联素的升高幅度均明显大于对照组，差异具有统计学意义（P<0.05）。结论丹参多酚酸盐能明显降低ACS患者血清中的抵抗素、CRP水平，升高脂联素水平，提示丹参多酚酸盐的治疗效果部分来自于其抗炎作用。

英文摘要:

Objective To explore effects of salvianolate on inflammatory cytokines （C reactive protein， resistin， and adiponectin） of patients with acute coronary syndrome （ACS）， and to analyze its possible treatment mechanisms for ACS patients. Methods Eighty three inpatients with ACS at the Cardiology Department of our hospital were randomly assigned to the treatment group and the control group from May 2011 to January 2012. Those in the treatment group （42 cases） were treated with routine Western medical treatment and intravenous injection of Salvianolate （200 mg/day）， while those in the control group （41 cases） were treated with routine Western medical treatment. The therapeutic course for all was 14 days. The serum levels of resistin，adiponectin， and CRP were observed before and after treatment. Results Compared with before treatment， the serum levels of resistin and CRP significantly decreased， and the serum level of adiponectin significantly increased in the two groups after treatment （P<0.05）. Besides， the decrement of serum levels of resistin and CRP and the increment of serum adiponectin level were obviously higher in the treatment group than in the control group， showing statistical difference between the two groups （P<0.05）. Conclusion Salvianolate could obviously reduce the serum levels of resistin and CRP， and increase the serum adiponectin level， indicating that partial therapeutic effects of salvianolate might come from its anti inflammation.

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