消脂胶囊治疗高脂血症的临床疗效研究

目的观察补益肝肾、健脾利湿法中药制剂消脂胶囊，对高脂血症患者血清总胆固醇（total cholesterol，TC）、甘油三脂（triglyceride，TG）、高密度脂蛋白（high-density lipoprotein cholesterol，HDL-C）、低密度脂蛋白（low-density lipoproteins cholesterol，LDL-C）及血浆内皮素（endothelin，ET）的影响及临床疗效。方法120例原发性高脂血症患者，随机分为治疗组80例口服消脂胶囊治疗，对照组40例口服血脂康胶囊治疗。治疗8周后，检测血清TC、TG、HDL-C、LDL-C及ET，并进行临床疗效评价。结果治疗组治疗后TC、TG、LDL-C、ET分别降低25.60%、33.70%、32.90%、11.02%，HDL-C升高24.20%，对照组TC、TG、LDL-C、ET分别降低24.80%、33.50%、31.30%、12.05%，HDL-C升高20.90%，两组分别与治疗前比较，差异有统计学意义（P<0.01）；但两组间比较差异无统计学意义（P>0.05）。两组治疗后主要症状积分较本组治疗前明显下降，差异有统计学意义（P<0.01），两组间比较差异无统计学意义（P>0.05）。两组治疗后眩晕、头重、心悸、胸闷、口干口渴症状，治疗组耳鸣症状较治疗前明显改善，差异有统计学意义（P<0.01）。治疗组与对照组临床疗效比较，总有效率分别为86.25%、82.50%，差异无统计学意义（P>0.05）。结论消脂胶囊治疗高脂血症，对患者血脂各项指标及ET有一定的作用，对临床症状有良好的改善作用，临床疗效可靠。

英文摘要:

ObjectiveTo observe the clinical effect and efficacy of Xiaozhi Capsule （XZC）， a Chinese medicine preparation for tonifying Gan-Shen， invigorating Pi to dissipate dampness （TGSIPDD） on total cholesterol （TC）， triglyceride （TG）， high-density lipoprotein cholesterol （HDL-C）， low-density lipoprotein cholesterol （LDL-C）， and endothelin （ET） in treating patients with hyperlipidemia. MethodsTotally 120 primary hyperlipidemia patients were randomly assigned to the treatment group （80 cases） and the control group （40 cases）. Those in the treatment group took XZC， while those in the control group took Xuezhikang Capsule （XZKC）. The serum TC， TG， HDL-C， LDL-C， and ET were detected and evaluated after 8 weeks of treatment. ResultsIn the treatment group TC was reduced by 25.60%， TG by 33.70%， LDL-C by 32.90%， and ET by 11.02%， while HDL-C was elevated by 24.20%. In the control group， TC was reduced by 24.80%， TG by 33.50%， LDL-C by 31.30%， and ET by 12.05%， while HDL-C was elevated by 20.90%. There was statistical difference in the two groups when compared with before treatment （P<0.01）. But there was no statistical difference in the aforesaid indices between the two groups after treatment （P>0.05）. The integrals for main symptoms after treatment obviously decreased in the two groups， showing statistical difference when compared with before treatment in the same group （P<0.01）. But there was no statistical difference in the aforesaid indices between the two groups （P>0.05）. After 8 weeks of treatment， symptoms such as vertigo， heavy sensation of head， palpitation， chest distress， dry mouth and thirsty were obviously improved after treatment. There was statistical difference in the improvement of tinnitus after treatment in the treatment group （P<0.01）. The total effective rate was 86.25% in the treatment group and 82.50% in the control group， showing no statistical difference （P>0.05）. Conclusions XZC showed certain effects on each blood lipid index and ET of hyperlipidemia patients. It had better improvement of clinical symptoms with reliable efficacy.

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