| 张晶,高继良,张乐,舒琦瑾.南方红豆杉水提物对肿瘤细胞增殖抑制作用的研究[J].中国中西医结合杂志,2013,33(6):0805-0809 |
| 南方红豆杉水提物对肿瘤细胞增殖抑制作用的研究 |
| Study on Inhibitory Effects of Taxus chinensis var. mairei Aqueous Extract on the Proliferation of Tumor Cells |
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| DOI：10.7661/CJIM.2013.06.0805 |
| 中文关键词: 南方红豆杉 抑制作用 人胃癌SGC-7901细胞 人乳腺癌MCF-7细胞 |
| 英文关键词:Taxus chinensis var. mairei inhibitory effect SGC-7901 cell MCF-7 cell |
| 基金项目:浙江省自然基金资助项目（No.Y2081051）；浙江省中医药管理局重点资助项目（No2009ZA003） |
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| 中文摘要: |
| 目的研究南方红豆杉水提物对人胃腺癌细胞株SGC-7901和人乳腺癌株MCF-7增殖的抑制作用和机制。方法采用二苯基四氮唑溴盐比色法（MTT法）检测南方红豆杉水提物和紫杉醇对SGC-7901和MCF-7细胞增殖的抑制作用；光镜观察其对2种细胞形态的影响；流式细胞仪检测其对2种细胞凋亡的影响。结果南方红豆杉水提物对肿瘤细胞的增殖有抑制作用；其抑制作用机制为诱导细胞凋亡。结论南方红豆杉水提物对肿瘤细胞的增殖有抑制作用。 |
| 英文摘要: |
| ObjectiveTo study the inhibitory effects of Taxus chinensis var. mairei Aqueous Extract （TAE） on SGC-7901 and MCF-7 cells， and to explore its mechanisms. MethodsThe inhibitory effects of TAT and Paclitaxel on the proliferation of SGC-7901 and MCF-7 cells were tested by MTT method. Their effects on the morphology of SGC-7901 and MCF-7 cells were observed by microscope. Its effects on the cell apoptosis were detected by flow cytometry. ResultsThe TAE had inhibitory effects on the proliferation of tumor cells， and its mechanisms were correlated to inducing the apoptosis of tumor cells. ConclusionTAE had inhibitory effects on the proliferation of tumor cells. |
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