不稳定心绞痛TIMI危险分层与中医血瘀证相关性研究

基金项目:“重大新药创制”科技重大专项资助项目（No. 2009ZX09502－031）；国家中医药管理局中医药行业科研专项资助项目（No. 200707001）；中医药行业科研专项资助项目（No. 201007001）；国家科技支撑计划资助项目（No. 2011BAZ03237）；国家973计划资助项目（No. 2006CB504803）

作者	单位	E-mail
钱伟,赵福海,吴伟
史大卓	中国中医科学院西苑医院心血管病中心（北京 100091）	heartmail@263.net

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中文摘要:

目的研究冠心病不稳定心绞痛（unstable angina pectoris，UAP）患者中医血瘀证积分与心肌梗死溶栓（thrombolysis in myocardial infarction，TIMI）危险评分的相关性，分析患者血瘀程度与UAP预后的关系。方法收集114例UAP住院患者一般资料、危险因素、中医症状、证候、冠状动脉造影结果、相关理化检查等，并计算患者Gensini积分、TIMI危险评分及血瘀证积分。结果 114例UAP患者的血瘀证积分与Gensini积分呈显著正相关（r=0.78， P<0.01）；冠状动脉三支病变患者血瘀证积分明显高于单支及双支病变患者（P<0.05）。TIMI评分高危组血瘀证积分明显高于中危组和低危组（P<0.01）；重度血瘀组的TIMI评分明显高于中度及轻度血瘀组（P<0.05， P<0.01）。血瘀证积分与TIMI危险评分呈显著正相关（r=0.23， P<0.05）。结论 UAP患者冠状动脉病变累及血管越多，血瘀程度越严重；UAP患者TIMI危险评分越高，血瘀程度越严重。

英文摘要:

Objective To study the correlation between thrombolysis in myocardial infarction （TIMI） risk stratification and blood stasis syndrome （BSS） score in patients with unstable angina pectoris （UAP）， and to analyze the relation of BBS degree and UAP clinical outcomes. Methods Collected were general data， demographic data， risk factors， Chinese medical symptoms and syndromes， coronary artery angiography results， relevant physical and chemical examinations from 114 UAP inpatients. Gensini score， TIMI risk score， and BSS score of these patients were calculated. Results The BBS score and Gensini score were significantly positively correlated（r=0.78， P<0.01）. The BBS score was significantly higher in those with lesion in three branches than those with lesion in one branch or in two branches（P<0.05）. The BBS score was significantly higher in the high risk group than in the lower risk group and the medium risk group（P<0.01）. The TIMI risk score was obviously higher in the severe blood stasis group than in the moderate blood stasis group and the mild blood stasis group （P<0.05， P<0.01）. The BBS score and TIMI risk score was positively correlated （r=0.23， P<0.05）. Conclusion The BBS score was positively correlated with more coronary arteries involved. The more severe BBS degree， the TIMI risk score more higher， and the BBS degree more syndrome.

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