维医异常黑胆质型哮喘患者IL-4基因多态性的变化特点

作者	单位	E-mail
克丽别娜·吐尔逊,地力木拉提·艾斯木吐拉,米合热古力·司马义
哈木拉提·吾甫尔	新疆医科大学维吾尔医药系（乌鲁木齐 830011）	halmurat@263.net

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中文摘要:

目的探讨新疆维吾尔族异常黑胆质型哮喘与白细胞介素－4（IL-4）基因多态性间的关系。方法对76例哮喘患者按维医体液论进行辨证分型，其中异常黑胆质型哮喘组30例，非异常黑胆质型哮喘组46例，并与健康对照组89名进行对照，采用聚合酶链反应－限制性片段长度多态性（PCR-RFLP）技术检测各组IL-4基因启动子区－589（C/T）位点的多态性。结果异常黑胆质型哮喘组IL-4基因启动子区－589（C/T）位点CT基因型分布频率明显高于非异常黑胆质型哮喘组和健康对照组，差异有统计学意义（P<0.01）；非异常黑胆质型哮喘组CT基因型分布频率明显高于健康对照组（P<0.05）；3组CC、TT基因型分布频率以及等位基因C、T的分布频率比较，差异均无统计学意义（P>0.05）。结论新疆维吾尔族异常黑胆质型哮喘可能与IL-4基因的启动子区－589（C/T）位点多态性有关。

英文摘要:

Objective To explore the relationship between the asthmatic Uyghur patients with abnormal Savda in Xinjiang and the gene polymorphism of interleukin-4 （IL-4）. Methods Totally 76 asthmatic patients were syndrome typed according to the body fluid theory of Uyghur medicine. Among them， there were 30 asthmatic patients with abnormal Savda and 46 asthmatic patients without abnormal Savda. A comparison study was performed in 89 healthy individuals （as the healthy control group）. The gene polymorphism of IL-4 promoter area-589 （C/T） site were detected by using PCR-RFLP. Results The distribution rate of genotype CT in asthmatic patients with abnormal Savda was significantly higher than that of the asthmatic patients with non-abnormal Savda and the healthy control group （P<0.01）. The distribution rate of genotype CT in asthmatic patients with non-abnormal Savda group was significantly higher than that of the healthy control group （P<0.05）. There was no difference in the distribution frequency of genotype CC or TT， or in the distribution frequency of allele C and T among the three groups （P>0.05）. Conclusion Asthma in Uyghur patients with abnormal Savda in Xinjiang might be correlated to the gene polymorphism of IL-4 promoter area-589 （C/T）.

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