18例丹参酮Ⅱ-A磺酸钠注射液不良反应的临床特点分析

目的探讨丹参酮ⅡA磺酸钠注射液不良反应的临床特点及其原因，为临床合理用药提供参考。方法检索丹参酮ⅡA磺酸钠注射液不良反应和配伍禁忌的文献报道（2000年1月—2011年12月国内医药学期刊），进行统计分析。结果 18例药品不良反应（adverse drug reaction，ADR）报告中，丹参酮ⅡA磺酸钠注射液不良反应的临床表现多样，皮肤及附件反应和神经肌肉系统反应各占50%，以老年人及女性为主，涉及器官系统多，存在诸多配伍禁忌。结论临床医务工作者应对丹参酮ⅡA磺酸钠注射液的不良反应引起高度重视，以避免不良反应的重复发生，规避风险，确保安全合理用药。

英文摘要:

ObjectiveTo explore clinical features the adverse reactions of Tanshinone ⅡA Sodium Sulfonate Injection （TⅡA SSI） and their reasons， thus providing reference for rational medication. MethodsThe literatures on adverse reactions and incompatibilities of TⅡA SSI were retrieved （domestic medical journals from January 2000 to December 2011） and statistically analyzed. ResultsIn the 18 cases of adverse drug reaction （ADR）， the clinical manifestations of TⅡA SSI induced adverse reactions were various， involving reactions of appendages and the neuromuscular system （each accounting for 50%）. The elderly and women were mainly involved. Many organs and systems were involved. There existed more incompatibilities. ConclusionThe medical workers should pay special attention to TⅡA SSI induced adverse reactions， thus avoiding recurrence of ADR， evading risks， and ensuring safe and rational medication.

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