参灵扶正胶囊和清毒胶囊治疗艾滋病的临床疗效分析

目的分析参灵扶正胶囊和清毒胶囊治疗艾滋病即获得性免疫缺陷综合征（acquired immunodeficiency syndrome，AIDS）的临床疗效。方法从数据库中选择资料完整、连续治疗6个月以上的AIDS病例共220例，按是否接受抗病毒治疗分为中医组（根据辨证结果给予参灵扶正胶囊或清毒胶囊，129例）和中西医结合组（参灵扶正胶囊或清毒胶囊联合高效抗逆转录病毒治疗，91例），分析两组治疗前，治疗后3、6个月症状体征总积分和单项积分、卡洛夫斯基积分和体重的变化，比较治疗前和治疗后6个月的CD4+细胞计数。结果两组治疗后3、6个月的症状体征总积分均低于治疗前（P<0.01），咳嗽、乏力、气短、呕吐、自汗、脱发、胸痛等单项症状体征积分下降（P<0.05，P<0.01），卡洛夫斯基积分均有所上升（P<0.05）。治疗后中医组体重有所增加（P<0.05），CD4+细胞计数低于治疗前（P<0.05），而中西医结合组治疗前后体重和CD4+细胞计数变化，差异均无统计学意义（P>0.05）。结论参灵扶正胶囊和清毒胶囊可改善AIDS患者的症状和体征，但未能阻止CD4+细胞计数的下降。

英文摘要:

ObjectiveTo analyze the clinical effectiveness of Shenling Fuzheng Capsule （SFC） and Qingdu Capsule （QC） in treating HIV/AIDS patients. MethodsTotally 220 patients with complete clinical data， who received consecutive treatment for 6 months were selected from the database. They were assigned to two groups whether they would rather receive antiretroviral drugs， the Chinese medicine （CM） treatment group and the integrative medicine （IM） group. The 129 patients in the CM group were treated with SFC or QC， while the 91 patients in the IM group were treated with SFC or QC combined highly active antiretroviral agents. Total score and single score of clinical symptoms and signs， Karnofsky Performance Status （KPS）， and changes of body weight before treatment， 3 and 6 months after treatment were compared. CD4+ cell counts were compared between before treatment and 6 months after treatment. ResultsThe total score of clinical symptoms and signs were lower at 3 and 6 months of treatment than before treatment respectively （P<0.01）. The single score of clinical symptoms and signs such as cough， weakness， shortness of breath， vomit， spontaneous perspiration， hair loss，and chest pain were also lowered at 3 and 6 months of treatment （P<0.05， P<0.01）， and the KPS increased （P<0.05）. The body weight increased （P<0.05） and CD4+ cell counts decreased （P<0.05） in the CM group. There was no statistical difference in body weight or CD4+ cell counts in the IM group between before and after treatment. ConclusionSFC and QC could improve clinical symptoms and signs of HIV/AIDS patients， but failed to deter the decrease of CD4+ cell counts.

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