糖尿病轻度认知障碍的影响因素及中医证素研究

基金项目:上海市临床重点专科建设项目-中医内分泌（No.shslczdzk05401）;国家自然科学基金资助项目（No.82074381，No.81874434）; 上海市科委科研计划项目（No.17401970100）;上海市中医临床重点实验室（No.20DZ2272200）;中医糖尿病专科联盟建设 [No.ZY（2018-2020）-FWTX-4011]

作者	单位
王骥远;耿艳娜;谭凌婕;陆灏	上海中医药大学附属曙光医院内分泌科（上海 201203）

摘要点击次数: 196

全文下载次数: 70

中文摘要:

目的探究糖尿病患者轻度认知障碍（MCI）的影响因素及中医证素特征。方法将249例糖尿病患者分为认知正常组（165例）及合并组（84例），比较两组患者发病率、年龄、文化程度、病程、并发症、用药情况、糖脂代谢指标，采用Logistic回归分析方法探究糖尿病合并MCI的影响因素；按照中医证候调查表采集中医四诊信息，分析糖尿病MCI的证素特征。结果 Logistic回归分析发现，60岁以下人群中，性别危险因素，男性糖尿病合并MCI风险是女性的5.07倍，文化程度高是保护因素（P=0.031）；在60岁以上人群中，合并糖尿病周围血管病变（P=0.019）、糖化血红蛋白控制差是危险因素（P=0.001），文化程度高是保护因素（P=0.000）。高中文化水平以下的患者，糖化血红蛋白控制差是危险因素（P=0.004）。MCI组人群证素特点：以阴虚证为主，其次为气虚、热、瘀；阴虚证患者中，最常见的3个症状是盗汗（72例）、潮热（67例）、腰酸（59例）。结论年龄大、血糖控制情况差是糖尿病患者合并MCI的危险因素，文化程度高则是保护因素。糖尿病合并MCI人群以阴虚证、气虚证为主，出现阴虚证症状的程度重。

英文摘要:

Objective To explore the influencing factors of mild cognitive impairment（MCI）in diabetes patients and the characteristics of Chinese medicine（CM） syndromes. Methods Totally 249 diabetic patients were divided into cognitive normal cognitive group（165 cases） and MCI group（84 cases）. The incidence，age，educational level，course of disease，complications，drug use，glucose and lipid metabolism indexes of the 2 groups were compared，and the influencing factors of MCI in diabetes patients were explored by Logistic regression analysis. The 4 diagnosis information of CM was collected according to the CM syndrome questionnaire to analyze the syndrome element characteristics of MCI in diabetes patients. Results Logistic regression analysis showed that in the population under 60 years old，the risk of male diabetes mellitus with MCI was 5.07 times higher than that of female，and high education level was the protective factor（P=0.031）. In the population over 60 years old，diabetic peripheral vascular disease （P=0.019），and poor control of HbA1c （P=0.000）were risk factors，high education was a protective factor（P=0.001）. Poor control of HbA1c was a risk factor for patients with high school education level or below（P=0.004）. The characteristics of syndrome elements in MCI group were mainly Yin deficiency syndrome，followed by qi deficiency，heat and blood stasis. Among patients with Yin deficiency syndrome，three of the most common symptoms were night sweats（72 cases），hot flashes（67 cases），and lumbar soreness（59 cases）. Conclusion Older age and poor glycemic control are risk factors for MCI in diabetic patients，while high education level is protective factors. Yin deficiency syndrome and qi deficiency syndrome are the main symptoms in diabetes MCI patients.

关闭