从代谢免疫角度谈病证结合防治冠心病

Understanding the Prevention and Treatment of Coronary Heart Disease Based on Disease-Syndrome Combination：From the Perspective of Immunometabolism

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DOI：10. 7661/j. cjim. 20230719.119

中文关键词: 代谢免疫病证结合冠心病中药中西医结合

英文关键词:immunometabolism disease-syndrome combination coronary heart diseases Chinese medicine integrative medicine

基金项目:国家中医心血管病临床医学研究中心专项科研基金（No.CMC2022009）;中国中医科学院科技创新工程项目（No.CI2021B004）

作者	单位
王安璐;徐浩	1.中国中医科学院西苑医院重症监护科（北京 100091）,2.中国中医科学院西苑医院心血管病中心，国家中医心血管病临床医学研究中心（北京 100091）

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中文摘要:

冠状动脉粥样硬化性心脏病（简称冠心病）是世界范围内具有高患病率和病死率的重大慢病。冠心病的发病过程中伴随着物质代谢紊乱和由此产生的慢性代谢性炎症，这提示代谢炎症有望成为防治冠心病的有效药物靶点。病证结合是中西医结合临床实践的重要模式，代谢免疫表型机制研究可帮助深入阐释病证结合的科学问题，深化病证结合和代谢免疫表型认识可为防治冠心病中药药效机制探索和创新药物研发提供新思路。

英文摘要:

Coronary heart disease （CHD） is a prevalent chronic condition that poses a significant global health burden in terms of morbidity and mortality. The pathogenesis of CHD involves metabolic disorders and the resultant chronic metaflammation， indicating that targeting metaflammation may be an effective therapeutic strategy for preventing and treating CHD. The concept of combining disease and syndrome represents an important pattern of clinical practice of integrated Chinese and Western medicine. Studying the mechanisms underlying the phenotype of immunometabolism can further enhance the understanding of the complex interactions between disease and syndrome. Consequently， delving into the pharmacodynamic mechanisms of Chinese medicine and developing innovative drugs can be facilitated by deepening knowledge of the phenotype of immunometabolism， thereby offering new prospects for the prevention and treatment of CHD.

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