夏枯草开音合剂改善早期喉癌激光术后嗓音及生活质量随机对照研究

Kaiyin Mixture of Spica prunellae Improves the Voice and Quality of Life after Laser Surgery for Early Glottic Laryngeal Carcinoma：A Randomized Controlled Trial

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中文关键词: T1a期声门型喉癌夏枯草开音合剂嗓音生活质量中药中西医结合

英文关键词:T1a glottic laryngeal carcinoma Kaiyin mixture of Spica prunellae voice quality of life Chinese herbal medicine integrative medicine

基金项目:上海市进一步加快中医药事业发展三年行动计划[No. ZY（2018-2010）-FWTX-3021]

作者	单位
龚姝婧;孙臻峰;罗丹;丁健;董频;王丽华;郭裕	1.上海交通大学医学院附属第一人民医院耳鼻咽喉科（上海 200080）,2.上海市中医医院耳鼻咽喉科（上海 200071）

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中文摘要:

目的观察夏枯草开音合剂对早期声门型喉癌CO2激光术后患者嗓音及生活质量的疗效。方法选择2019年9月—2021年6月就诊于上海市第一人民医院的52例T1a期声门型喉癌患者，按随机数字法分为治疗组（26例）和对照组（26例），行Ⅲ-Ⅴa型CO2激光术，治疗组服用夏枯草开音合剂，对照组服用安慰剂，各服用1个疗程（3个月），同时辅以嗓音训练，随访6个月。通过两组患者术后1、3、6个月的嗓音声学分析和嗓音障碍指数及生活质量量表观察，评价夏枯草开音合剂的治疗效果。结果两组患者术后1个月各项指标比较，差异无统计学意义（P>0.05）。术后3个月时，治疗组标准化噪声能量（NNE）、谐噪比（HNR）及嗓音障碍指数（VHI）中的“生理”范畴评分优于对照组（P＜0.05）。术后6个月，治疗组基频微扰（ Jitter）、振幅微扰（ Shimmer）、NNE、HNR、VHI和生活质量评分均优于对照组（P＜0.05）。结论夏枯草开音合剂有助于改善T1a期声门型喉癌CO2激光术后患者的嗓音及生活质量。

英文摘要:

Objective To observe the effect of Kaiyin Mixture of Spica prunellae on voice and quality of life of patients with early glottic laryngeal cancer after CO2 laser surgery. Methods A total of 52 patients with stage T1a glottic laryngeal carcinoma who visited Shanghai First People's Hospital from September 2019 to June 2021 were randomly assigned to treatment group （26 cases）and control group（26 cases）according to random number. Both groups received typeⅢ-Ⅴa CO2 laser，the treatment group received Kaiyin Mixture of Spica prunellae，and the control group received placebo，each taking a course of treatment（3 months），supplemented by voice training，and followed up for 6 months. The voice acoustic analysis，voice handicap index and Quality of Life Scale were collected at 1，3 and 6 months after operation for observation and comparison. Results There was no significant difference in the indicators between two groups at 1 month after surgery（P>0.05）. At 3 months after surgery，the normalized noise energy（NNE），harmonics to noise ratio（NHR） and the scores in the "physiological" category of the voice handicap index（VHI）scale of the treatment group，were better than those of the control group（P<0.05）. At 6 months after surgery，the data of Jitter，Shimmer，NNE，HNR，VHI scale and quality of life score of the treatment group were better than those of the control group （P<0.05）. Conclusion Kaiyin Mixture of Spica prunellae could improve the voice and quality of life of patients with early glottic laryngeal cancer after CO2 laser surgery.

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