| 徐理纳,欧阳蓉,王建平.几种活血化瘀药和乙酰水杨酸对大鼠动脉壁前列腺环素样物质的生成和血小板聚集性的影响[J].,1981,(1):36-38,23,64 |
| 几种活血化瘀药和乙酰水杨酸对大鼠动脉壁前列腺环素样物质的生成和血小板聚集性的影响 |
| Influence of Dang-Gui(Angelica sinensis)Sodium ferulate the Total Glucoside of Chi Shao(Paeonia lactiflora)Tetramethylpyrazine and Acetylsalicylic Acid on Rat Arterial Tissue Prostacyclin-like Substance Production and Platelet Aggregation |
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| DOI： |
| 中文关键词: 血小板聚集作用 血小板聚集性 动脉壁 前列腺环素 乙酰水杨酸 血小板凝集素 正常大鼠 阿魏酸钠 环氧化酶 抑制血小板聚集 |
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| 中文摘要: |
| 近年来的研究说明,机体内有一对相互制约、相互拮抗的细胞功能调节因子,即血小板凝集素A2(T-XA2和前列腺环素（PGI2）。TXA2为血小板聚集最强诱导剂,并有收缩血管作用,由血小板合成,PGI2则与之相反,为血小板聚集最强抑制剂,有扩张血管作用,由血管内皮细胞合成,血栓的形成过程受 T-XA2和 PGI2的调节和控制。凡对抗 TXA2或增强 P-GI2的药物必将有利于血栓一栓塞性疾病的防治。 |
| 英文摘要: |
| The traditional Chinese Hun Xue Hua Yu（活血化瘀,HXHY）drugs（medicines for the treatment of blood stasis and for the stimulation of blood circulation）and acetylsalicylic acid（ASA）have been used in clinical experiments for the treatment of thrombo-embolic diseases.The present paper describes the influence of several HXHY drugs and ASA on rat arterial tissue prostacyclin PGI2-like substance production and platelet aggregation. Rats weighing 200g or more were used.Blood was collected under pentobarbital anesthesia and platelet aggregation induced with adenosine diphosphate（ADP）was measured.Rat arterial segments were incubated with normal rat platelet rich plasma（PRP）before the addition of ADP.The anti-aggregating action of rat arterial tissue PGI2-like substance was estimated. when ASA was given intravenously（15mg/kg）or orally（300mg/kg）the platelet aggregation was inhibited by 50% or more.At the same time,the arterial tissue PGI2-like substance activity was inhibited by 79-100%. Dang-Gui（当归,Angelica sinensis,20g/kg iv）or one of its components（Sodium ferulate,200mg/kg iv）also inhibited platelet aggregation by 50% or more.In contrast to ASA,they showed no significant effect on the production of the total glycoside of Chi-Shao（赤芍）,Paeonia lactiflora)at a dose of 525mg/kg inhibited rat. platelet aggregation by 41% while the generation of arterial wall PGI2-like substance was not affected.Neither platelet aggregation nor PGI2-like substance production was influenced by intravenous administration of tetramethylpyrazine（one of the effective constituents in Chuan-Xiong 川芎,Ligusticum wallichii）at a dose of 40mg/kg. |
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