| 何愉生,吴余昇,吕恩武,李佩莉,张昌兴,王岩松,王梦林,陈可翼.赤芍精抗血小板聚集作用的临床及实验研究[J].,1982,(1):15-18,62,65,66,21 |
| 赤芍精抗血小板聚集作用的临床及实验研究 |
| A Clinical and Experimental Study on Anti-platelet Aggregation Effect of d-Catechin(赤芍精) |
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| 中文关键词: 抗血小板聚集作用 冠心病心绞痛 血小板功能 赤芍 动脉条 实验研究 血小板聚集性 表面活性 兔主动脉 聚集数 |
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| 中文摘要: |
| 赤芍(Paeonia lactiflora Pall.)是代表性的活血化瘀药之一。经方与古方中以赤芍组成的活血化瘀方剂很多。近年北京地区冠心病协作组按祖国医学活血化瘀治则拟定的冠心Ⅱ号复方在治疗冠心病心绞痛中亦取得了一定疗效。湖南医药工业研究所最近从湖南廉桥镇出产的赤芍中分离出一种有效成分赤芍精(即d-儿茶精,d-Catechin),化学结构式为 |
| 英文摘要: |
| d-Catechin（赤芍精）is extracted from Chi-shao（赤芍,Paeonia lactiflora）,one of the active components of a TCM in common use Huo Xue Hua Yu herb（活血化瘀药）.In animal experiments,a TXA2-like substance was produced through the incubation of arachidonic acid and rabbit PRP.After adding d-catechin or aspirin into PRP separately（terminal concentration is 0.1% each）,the inhibition rates of biosynthesis of the TXA2-like substance were 39.5% and 37.2% respectively.The inhibition rate of the biological activity of the TXA2-like substance that contracted rabbit’s aortic strips was 54.4% following the addition of d-catcehin into the bath. In clinical study,the single blind randomized control method was employed to observe the clinical effects in 22 patients with angina pectoris due to coronary heart disease.The patients were treated with d-catechin on surface activation and aggregation of blood platelet under electronmicroscope following the modified Schatz method.The results showed that the patients spread type platelets decreased from 41±2.3% to 25±1.6%,and the aggregation number decreased from 117±10 to 48±10.9 after one course treatment（200-250 mg/day）with intravenous infusion of d-catechin.No significant influence on spread type platelets and aggregation number was found while the patients were treated with normal saline as control（20 ml/day,intravenously）. The cAMP level within the patient’s platelets determined by radioimmunoassay tended to rise（from 10±1 to 13±2 Pmol/130×104 platelet,P>0.05）following a single dose（250 mg）of intravenous d-catechin.The anti- anginal attack efficacy of d-catechin was 16/21,and the ECG improvement 7/22. |
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