| 葛振华,刘文新.烘绑法合并海群生治疗晚期丝虫象皮肿的病理及组织化学初步研究[J].,1982,(2):106-108,130,69 |
| 烘绑法合并海群生治疗晚期丝虫象皮肿的病理及组织化学初步研究 |
| A Preliminary Study on the Change in Pathology and Histochemistry of Affected Limbs in Filarial Elephantasis after the Treatment with the Baking-Bandage Method and Hetrazan |
| |
| DOI： |
| 中文关键词: 象皮肿 组织化学 海群生 弹性纤维 治疗后 治疗方法 烘绑疗法 炎症细胞 丝虫 乳头层 |
| 英文关键词: |
| 基金项目: |
|
| Hits: 1775 |
| Download times: 946 |
| 中文摘要: |
| 由丝虫引起的下肢象皮肿,目前还没有较理想的治疗方法,虽然海群生在防治方面有一定作用,但不能使象皮肿消退。福建省有关单位应用民间烘绑疗法加海群生治疗象皮肿,取得了一些经验。经过临床观察和多年随访,证明有肯定疗效。为了探究其治疗机理,我们从病理形态学和组织化学等方面作了初步观察,报告如下。 |
| 英文摘要: |
| Relatively satisfactory results have been obtained in the treatment of 17 patients with advanced filarial elephantasis with both the baking-bandage method and hetrazan,and changes in morphology and histochemistry in sections have also been observed with the following results. 1.The effects on the local:After treatment,the inflammation in the patients’ affected limbs disappeared,the nutritional condition of tissue was improved.As a result,the sweat glands and hair follicles began to regenerate,the secreting function of the sweat glands gradually restored and elastic fibers in dermis reappeared too.It was found that the amount of acid mucopolysaccharides in the base is related to the formation of elastic fibers.As the nutrition of oxtracellular environment has been improved,the cell metabolism and mitosis were restored shortly.Glycogen plays an important role during the cell division and is also an energy donor.After treatment,glycogen disappeared in the epidermis,which then resembled the normal. The above-mentioned reduction of the size of affected limbs was due to following reasons.First,the inflammation caused by filarias was suppressed.Second,the edema and inflammation in the dermis disappeared.A pressure by means of the baking- bandage method was added to affected limbs instead of the action of the elastic fibers in the dermis. 2.The effects on organism:The clinical practice has demonstrated that inflammation might be temporarily suppressed after the patients were treated with the baking-bandage method.The effect probably influenced the organism through the local,and strenthened the defensive function of the whole body,Besides,the method could also raise the ability to defend the pathogenic agents.but the baking-bandage method does not kill the filafias in the body.So loog as the patients’ health worsens,inflammation will reoccur immediately.During the period,the IgG in the patients’ sera increased.A lot of Ig granules could be seen below the endothelium of vessels,demonstrable with the immunoenzymatic technique.The Ig granules could stimulate the complements which attract the white cells to release various enzymes that will produce the inflammatory reactions,so the permeability of vessels increases.That is why the limb swells.After the patients had taken Hetrazan,the pathogenic agents were controlled.Subsequently,the frequency of inflammatory attacks decreased.The deposited Ig in the vessel walls disappeared too,so the permeability of vessels was restored to normal again.On the other hand,as the elastic fibers in vessels remarkedly increased,the backflow of liquid was promoted.With the help of the baking-bandage method,the vicious circle tarned into the benign circle. 3.Evaluation of the therapy:According to clinical experiences in our province,the size of the affected limbs of the patients who only took Hetrazan could not be reduced.The mere use of the baking-bandage method was also ineffective.In order to achieve a good efficiency in the treatment of elephantasis,one must apply the integration of traditional and western medicine, for it has manifested a remarkably effective result.Both baking and bandage are necessary,but the filarias could not be killed. Furthermore,they have a disadvantage,that is,it took longer time to treat the patients,so a few patients could not follow the treatment to the end.However,the therapy still remains the best one in the treament of elephantasis at prepsent. |
| View Full Text View/Add Comment Download reader |
|
|
|
